18α-甘草酸的合成工艺研究

Study on synthetic process of 18α-glycyrrhizic acid

摘要

优化 18α-甘草酸的合成工艺。以 18β-甘草酸单铵盐为起始原料，经异构化、酯化和水解反应得到目标化合物 18α-甘草酸。目标化合物及关键中间体的结构经¹H NMR、¹³C NMR 和 HRMS 确证，目标化合物的总收率为 9.43%，纯度为 99.23%，杂质 A 的含量为 0.17%。优化后的工艺显著提高了异构化转化率，降低了有关物质的生成，简化了纯化工序，更有利于工业化生产和成本控制。

Abstract

In this study, the synthetic process of 18α-glycyrrhizic acid was optimized. Using 18β-glycyrrhizic acid monoammonium salt as the starting material, the target compound 18α-glycyrrhizic acid was obtained through isomerization, esterification, and hydrolysis, with a total yield of 9.43%, purity of 99.23% and key impurity A of 0.17% (HPLC). The optimized process significantly improved the isomerization conversion rate, reduced the formation of related substances, simplified the purification steps, and enhanced both industrial scalability and cost efficiency.

关键词

18α-甘草酸 / 合成 / 工艺优化

Key words

18α-glycyrrhizic acid / synthesis / process optimization

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基金资助

甘肃省科技专员专项(25CXGA029)

国家自然科学基金项目(82560852)