包芯片制备技术介绍及药学研究探讨

An introduction to tablet in tablet technology and discussion on pharmaceutical research

摘要

包芯片制备技术作为一种新型的药物制剂技术,运用特定的压制工艺,将药物活性成分或含药层包裹于中间,外层覆盖一层或多层具备不同功能（如保护、缓释/控释、隔离等）包衣层的药物制剂形式。包芯片通过特殊的制备工艺与结构设计,赋予药物独特的释药特性与功能特性,从而实现对药物释放的精准调控,提升药物的稳定性,并改善药物的其他性能,近年来受到广泛关注。本文通过相关文献调研,概述包芯片制备技术发展历程、制备技术原理、制备技术特点,结合包芯片制备技术的创新应用进行阐述,并对药学研究进行探讨,以期为该类制剂研究开发提供一定参考。

Abstract

Tablet in tablet technology,as a new type of drug formulation technology,uses a specific pressing process to wrap the active ingredient or drug containing layer in the middle,and the outer layer is covered with one or more coating layers with different functions such as protection,sustained and controlled release,isolation,etc.. Tablet in tablet technology endows drugs with unique drug release and functional characteristics through special preparation processes and structural design,thereby achieving precise regulation of drug release,enhancing drug stability,and improving other drug properties.In recent years,it has received widespread attention.This article summarizes the development history,principles,and characteristics of tablet in tablet technology through relevant literature research.It also elaborates on the innovative applications of tablet in tablet technology and explores pharmaceutical research,in order to provide some references for the research and development of such formulations.

关键词

包芯片技术 / 压制包芯片 / 一步干法包芯片 / 制备技术 / 药学研究

Key words

tablet in tablet technology / compression-coated tablets / one-step dry-coated tablets / preparation technology / pharmaceutical research

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