LTBP2、COL4A3、CA125与非小细胞肺癌临床病理特征的相关性及临床意义

Correlation Analysis and Clinical Significance of Serum LTBP2, COL4A3, CA125 Levels with Clinicopathological Features of Patients with Non-small Cell Lung Cancer

摘要

目的 探讨血清转化生长因子结合蛋白2（LTBP2）、Ⅳ型胶原蛋白α3（COL4A3）、糖类抗原125（CA125）水平与非小细胞肺癌（NSCLC）患者临床病理特征的相关性及诊断价值。方法 选取2021年5月~2023年5月周口市中心医院收治的NSCLC患者97例,纳入观察组,另选取肺部良性病变患者97例,纳入对照组。采用双抗酶联免疫吸附法测定血清LTBP2、COL4A3,采用双抗体夹心法测定血清CA125水平,比较2组患者血清各指标水平,分析各指标水平与病理特征的相关性及联合检测对NSCLC的诊断价值。结果 观察组血清LTBP2、COL4A3、CA125水平高于对照组（P<0.05）;不同TNM分期、浸润深度、淋巴结转移患者血清LTBP2、COL4A3、CA125水平比较：Ⅲ~Ⅳ期>Ⅰ~Ⅱ期、T3+T4>T1+T2、伴有淋巴结转移>无淋巴结转移（P<0.05）;血清LTBP2、COL4A3、CA125水平与NSCLC患者TNM分期、浸润深度、淋巴结转移均呈正相关,且各指标联合诊断NSCLC的AUC为0.889,最佳敏感度、特异度分别为90.72%、84.54%,约登指数为0.753。结论 血清LTBP2、COL4A3、CA125水平与NSCLC患者临床病理特征呈正相关,联合检测对NSCLC具有一定诊断价值,可作为临床诊断NSCLC辅助指标。

Abstract

Objective To investigate the correlation between serum laten transforming growth factor binding protein 2 (LTBP2), type Ⅳ collagen α3 (COL4A3), carbohydrate antigen 125 (CA125) levels and clinicopathological features in patients with non-small cell lung cancer (NSCLC) and their diagnostic value. Methods A total of 97 patients with NSCLC admitted to Zhoukou Central Hospital from May 2021 to May 2023 were included in the observation group, and 97 patients with benign lung lesions were included in the control group. The serum levels of LTBP2 and COL4A3 were measured by double antibody enzyme-linked immunosorbent assay, and the serum levels of CA125 were measured by double antibody sandwich method. The serum levels of the two groups were compared, and the correlation between the levels of each index and pathological characteristics and the diagnostic value of combined detection for NSCLC were analyzed. The correlation between each index level and pathological characteristics was analyzed, as well as the diagnostic value of combined detection in NSCLC. Results Serum LTBP2, COL4A3 and CA125 levels in observation group were higher than those in control group (P<0.05). Serum levels of LTBP2, COL4A3 and CA125 in patients with different TNM stages, depth of invasion and lymph node metastasis were compared: Ⅲ~Ⅳ>Ⅰ~Ⅱ, T3+T4 > T1+T2, with lymph node metastasis > without lymph node metastasis (P<0.05). Serum levels of LTBP2, COL4A3 and CA125 were positively correlated with TNM stage, invasion depth and lymph node metastasis in NSCLC patients. The AUC of all indexes in the combined diagnosis of NSCLC was 0.889, the best sensitivity and specificity were 90.72% and 84.54%, respectively, and the Yoden index was 0.753. Conclusion Serum LTBP2, COL4A3 and CA125 levels are positively correlated with clinicopathological features of patients with NSCLC. Combined detection has certain diagnostic value for NSCLC, and can be used as auxiliary indicators for clinical diagnosis of NSCLC.

关键词

转化生长因子结合蛋白2 / Ⅳ型胶原蛋白α3 / 糖类抗原125 / 非小细胞肺癌 / 临床病理特征

Key words

Laten transforming growth factor binding protein 2 / Type IV collagen α3; / Carbohydrate antigen 125 / Non-small cell lung cancer / Clinicopathological features

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