颈动脉斑块METmRNA表达与缺血性脑血管病的相关性

Correlation between METmRNA Expression in Carotid Artery Plaques and Ischemic Cerebrovascular Disease

摘要

目的 探讨颈动脉斑块中METmRNA表达与缺血性脑血管病症（ICVD）发生的相关性,为缺血性脑血管病的预防和治疗提供参考。方法 纳入新密市中医院2021年1月~2023年3月收治的行颈动脉内膜剥脱术的ICVD患者97例,根据检出斑块性质分为易损组、非易损组、并存组,采用qRT-PCR法检测剥离斑块METmRNA,分析METmRNA表达量与斑块性质、ICVD类型、ICVD严重程度的相关性。结果 易损组、非易损组、并存组mRNA表达量分别为0.763±0.047、0.591±0.039、0.708±0.043,差异有统计学意义,均P<0.05;短暂性脑缺血、脑梗死、脑动脉盗血综合征、慢性脑缺血四类患者间mRNA表达量分别为0.711±0.068、0.765±0.077、0.655±0.071、0.671±0.083,差异有统计学意义,均P<0.05;NIHSS分级轻度、中度、中重度、重度患者间mRNA表达量分别为0.642±0.072、0.671±0.074、0.754±0.039、0.789±0.051,差异有统计学意义,均P<0.05;颈动脉斑块中METmRNA表达量与斑块类别、ICVD分类、NIHSS分级、颈动脉狭窄分级、空腹血糖、总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白显著相关,均P<0.05。结论 颈动脉斑块中METmRNA表达与ICVD的发生显著相关,主要通过参与斑块不稳定性发展导致短暂性脑缺血、脑梗死的发生,并与高血糖、高脂血症存在相互作用。

Abstract

Objective To investigate the correlation between the expression of MET mRNA in carotid artery plaques and the occurrence of ischemic cerebrovascular disease (ICVD), in order to provide reference for the prevention and treatment of ischemic cerebrovascular disease. Method 97 ICVD patients who underwent carotid endarterectomy in our hospital from January 2021 to March 2023 were included. They were divided into vulnerable, non vulnerable, and coexisting groups based on the nature of the detected plaques. The MET mRNA of the stripped plaques was detected using qRT PCR method, and the correlation between MET mRNA and plaque nature, ICVD subtypes, and ICVD severity was analyzed. Results The mRNA expression levels in the vulnerable group, non vulnerable group, and coexisting group were 0.763 ± 0.047, 0.591 ± 0.039, and 0.708 ± 0.043, respectively, with statistically significant differences (P<0.05). The mRNA expression levels among patients with transient cerebral ischemia, cerebral infarction, cerebral steal syndrome, and chronic cerebral ischemia were 0.711 ± 0.068, 0.765 ± 0.077, 0.655 ± 0.071, and 0.671 ± 0.083, respectively, with statistically significant differences (P<0.05). The mRNA expression levels among patients with mild, moderate, moderate, and severe NIHSS grading were 0.642 ± 0.072, 0.671 ± 0.074, 0.754 ± 0.039, and 0.789 ± 0.051 respectively, with statistically significant differences (P<0.05). The expression level of MET mRNA in carotid plaques was significantly correlated with plaque type, ICVD classification, NIHSS grading, carotid stenosis grading, fasting blood glucose, total cholesterol, triglycerides, high-density lipoprotein, and low-density lipoprotein, all P<0.05. Conclusion The expression of MET mRNA in carotid artery plaques is significantly correlated with the occurrence of ICVD, mainly by participating in the development of plaque instability leading to transient cerebral ischemia and stroke, and interacting with hyperglycemia and hyperlipidemia.

关键词

颈动脉斑块 / MET mRNA表达量 / 易损斑块 / 缺血性脑血管病

Key words

Carotid artery plaque / MET mRNA expression level / Vulnerable plaques / Ischemic cerebrovascular disease

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