血浆CD89、PRDX1和AOPP水平在过敏性紫癜非肾型和肾型患者中的临床意义

Clinical Significance of Plasma CD89, PRDX1 and AOPP in Patients with Non-renal Henoch-Schonlein Purpura and Renal Purpura

摘要

目的 回顾性研究CD89、PRDX1和AOPP在过敏性紫癜非肾型及肾型组中表达差异,为HSP发病机制及早期识别肾型紫癜提供参考。方法 选取2020年12月~2023年4月于承德医学院附属医院确诊为过敏性紫癜的患者104例,并依据尿检结果,将其分为非肾型紫癜组（47例）和肾型紫癜组（57例）,另选同时期体检科健康体检者为正常对照组（57例）。采用ELISA法检测各组CD89、PRDX1和AOPP的血浆水平。采用非参数检验和二元回归方程对结果进行分析,以ROC曲线分析血浆CD89、PRDX1和AOPP各自及联合对HSP肾型的诊断价值。结果 肾型紫癜组血浆CD89、PRDX1和AOPP水平显著高于正常对照组及非肾型紫癜组,且非肾型紫癜组显著高于正常对照组,差异均有统计学意义（P<0.05）,多因素Logistic回归方程显示：CD89、PRDX1和AOPP的升高对肾型紫癜的影响具有统计学意义。ROC曲线显示三者联合对肾型紫癜有着更好的预测价值。结论 血浆CD89、PRDX1和AOPP可能参与了过敏性紫癜及其肾型的发病,三者联合检测对HSP肾损害的发生的预测具有较好的临床价值。

Abstract

Objective The clinical significance of plasma CD89, PRDX1 and AOPP in the patients with non-renal henoch-schonlein purpura (HSP) and renal purpura was analyzed retrospectively, in order to provide references for the pathogenesis of HSP and early identification of renal purpura. Methods One hundred and four patients diagnosed with HSP in the Affiliated Hospital of Chengde Medical University from December 2020 to April 2023 were chosen as the study object. Patients were divided into non-renal purpura group (47 cases) and renal purpura group (57 cases) according to the results of urine test. Fifty-seven healthy people at the same time were chosen from the physical examination department as normal control group. The plasma levels of CD89, PRDX1 and AOPP in each group were measured by ELISA. Kruskal Wallis test and binary logistic regression were used for data comparison analysis and correlation analysis. ROC curve was applied to analyze the value of plasma CD89, PRDX1 and AOPP in the diagnosis of renal purpura. Results The plasma levels of CD89, PRDX1 and AOPP of renal purpura group were significantly higher than the levels of normal control group and non-renal purpura group, the results of non-renal purpura group were significantly higher than those of normal control group, there were statistically significant differences (P<0.05). Multivariate Logistic regression equation indicated that the effect of them on renal purpura was statistically significant. ROC curve shows that the combination of three factors has higher value in predicting the occurrence renal purpura. Conclusion Plasma CD89, PRDX1 and AOPP may be involved in the pathogenesis of HSP and renal purpura. The combination of plasma CD89, PRDX1 and AOPP has good clinical value in the diagnosis of renal purpura .

关键词

过敏性紫癜 / 肾型紫癜 / CD89 / PRDX1 / AOPP

Key words

henoch-schonlein purpura / renal purpura / CD89 / PRDX1 / AOPP

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