KIF3B mRNA表达水平与皮肤基底细胞癌病理特征的关联研究

Study on the correlation between KIF3B mRNA and pathological features of basal cell carcinoma of the skin

摘要

目的 分析驱动蛋白家族成员3B信使RNA（KIF3B mRNA）与皮肤基底细胞癌（BCC）患者病理特征的关联。方法 回顾性分析河南科技大学第二附属医院2023年1月—2024年12月经病理诊断的72例BCC患者标本,以及来自门诊患者手术切除的带有正常皮肤组织的20例标本,分别列为病例组和对照组,比较2组KIF3B mRNA表达水平差异。依据病灶的病理亚型,将72例BCC患者分别列为硬化型基底细胞癌组（即侵袭性基底细胞癌组,IBCCs）和结节型及浅表型组（即非侵袭性基底细胞癌组,NIBCCs）,比较2组患者KIF3B mRNA表达水平及病理特征的差异,分析KIF3B mRNA表达水平与其病理特征间的相关性,以及对BCC的预测效能。结果 病例组的KIF3B mRNA表达水平高于对照组（P<0.05）。IBCCs组的KIF3B mRNA表达水平高于NIBCCs组（P<0.05）。IBCCs组的皮损直径>1 cm占比、深部侵袭占比均高于NIBCCs组（P<0.05）。KIF3B mRNA表达水平与BCC患者的皮损直径、深部侵袭占比呈正相关（P<0.05）。KIF3B mRNA表达水平对BCC的预测灵敏度、特异度分别为89.23%、75.35%（AUC=0.866）。结论 KIF3B mRNA在BCC患者中高水平表达,其表达水平与患者病理特征密切相关,通过检测KIF3B mRNA表达水平可早期识别BCC发病风险。

Abstract

Objective The correlation between the expression of KIF3B mRNA and the pathological characteristics of skin basal cell carcinoma. Methods Retrospective analysis of 72 specimens of BCC patients diagnosed by pathology and 20 specimens with normal skin tissue surgically removed from outpatient patients in our hospital from January 2023 to December 2024. Divide them into a case group and a control group, and the differences of KIF3B mRNA expression levels between the two groups were compared. Based on the pathological subtypes of the lesions, 72 BCC patients were classified into sclerosing basal cell carcinoma group (i.e. invasive basal cell carcinoma group, IBCCs) and nodular and superficial phenotype group (i.e. non-invasive basal cell carcinoma group, NIBCCs). The differences of KIF3B mRNA expression levels and pathological features between the two groups of patients were compared, and the correlation between KIF3B mRNA and its pathological features was analyzed, as well as its predictive power for BCC. Results The expression level of KIF3B mRNA in the case group was higher than that in the control group (P<0.05). The expression level of KIF3B mRNA in IBCCs group was higher than that in NIBCCs group (P<0.05). The proportion of lesions with diameter>1cm and the proportion of deep invasion in the IBCCs group were higher than those in the NIBCCs group (P<0.05). The expression level of KIF3B mRNA was positively correlated with the lesion diameter and the proportion of deep invasion in BCC patients (P<0.05). The sensitivity and specificity of KIF3B mRNA expression level in predicting BCC were 89.23% and 75.35%, respectively (AUC=0.866). Conclusion KIF3B mRNA is highly expressed in BCC patients, and its expression level is closely related to the pathological characteristics of BCC patients. Detection of KIF3B mRNA expression level can early identify the risk of BCC.

关键词

皮肤基底细胞癌 / KIF3B / 病理分期 / 病理特征 / 预测效能

Key words

basal cell carcinoma of the skin / KIF3B / pathological staging / pathological features / predictive efficiency

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基金资助

河南省医学科技攻关项目(LHGJ20201020127)