circRNA-miRNA-mRNA竞争性内源RNA调控网络在急性髓系白血病中的研究进展

摘要

环状RNA（circRNA）在急性髓系白血病（AML）中常有异常表达,并可作为分子“海绵”特异性吸附相应微小RNA（miRNA）,调节下游靶基因信使RNA（mRNA）的转录表达。circRNA的表达上调或下调,可构建成相应的circRNA-miRNA-mRNA竞争性内源RNA（ceRNA）网络,影响AML肿瘤发生、发展、耐药及预后,是AML肿瘤相关机制研究热点。本文就近年来circRNA-miRNA-mRNA相关ceRNA调控网络在AML中的相关研究进展做一综述,旨在为探索急性白血病的诊断、治疗及预后评估相关靶点或通路提供新思路。

关键词

环状RNA / 微小RNA / 信使RNA / 竞争性内源RNA / 急性髓系白血病

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基金资助

安徽省卫生健康科研项目(AHWJ2024Ab0028); 安徽省中医药传承创新科研项目（2025CCCX102）; 安徽省慢性疾病免疫学基础与临床重点实验室开放研究基金项目（MBDX202409）; 蚌埠医学院自然科学重点项目（2022byzd078）; 蚌埠市科技创新指导类项目（20230135）; 蚌埠医科大学-齐鲁制药有限公司2025年临床研究合作专项项目（BY-QLYB048）