心脏内膜肉瘤1例

关键词

心脏肿瘤 / 内膜肉瘤 / MDM2基因 / 鉴别诊断

[1] Gupta R, Meghrajani V, Desai R, et al.Primary Malignant Cardiac Tumors: A Rare Disease With an Adventurous Journey[J]. J Am Heart Assoc, 2020, 9(10): e016032.
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[5] Badge V S, Kohale M, Patil A, et al.Spindle-cell sarcoma of the heart: A case report of a rare cause of cardiac mass[J]. Ann Card Anaesth, 2022, 25(2): 220-224.
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[7] Van Dievel J, Sciot R, Delcroix M, et al.Single-Center Experience with Intimal Sarcoma, an Ultra-Orphan, Commonly Fatal Mesenchymal Malignancy[J]. Oncol Res Treat, 2017, 40(6): 353-359.
[8] Bode-Lesniewska B, Zhao J, Speel E J, et al.Gains of 12q13-14 and overexpression of mdm2 are frequent findings in intimal sarcomas of the pulmonary artery[J]. Virchows Arch, 2001, 438(1): 57-65.
[9] Koyama T, Shimizu T, Kojima Y, et al.Clinical Activity and Exploratory Resistance Mechanism of Milademetan, an MDM2 Inhibitor, in Intimal Sarcoma with MDM2 Amplification: An Open-Label Phase Ib/II Study[J]. Cancer Discov, 2023, 13(8): 1814-1825.
[10] Koelsche C, Benhamida J K, Kommoss F K F, et al. Intimal sarcomas and undifferentiated cardiac sarcomas carry mutually exclusive MDM2, MDM4, and CDK6 amplifications and share a common DNA methylation signature[J]. Mod Pathol, 2021, 34(12): 2122-2129.
[11] Ito Y, Maeda D, Yoshida M, et al.Cardiac intimal sarcoma with PDGFRβ mutation and co-amplification of PDGFRα and MDM2: an autopsy case analyzed by whole-exome sequencing[J]. Virchows Arch, 2017, 471(3): 423-428.

基金资助

江苏省卫生计生委科研课题（H2017075）,江苏省泰州市大健康产业创新能力提升（社会发展）非企业项目（TS202309）