高强高模和低水渗透性超高分子量聚乙烯机织覆膜研究

Research on UHMWPE woven graft cover with high strength, high modulus, and low water permeability

摘要

覆膜支架在临床治疗主动脉瘤方面发挥着不可替代的作用。目前,商用覆膜支架中的覆膜主要为聚对苯二甲酸乙二醇酯(PET)机织材料。长期的临床实践发现,PET机织覆膜的水渗透性较高,通常需要后处理,且覆膜破损的案例时有报道。超高分子量聚乙烯(UHMWPE)材料具有高强高模的性能特点,在运动医学领域已有广泛应用。研究将UHMWPE纱引入支架覆膜,制备UHMWPE机织覆膜和PET/UHMWPE机织覆膜,并与相同纱线规格的PET机织覆膜进行系统地对比和分析,探究开发高强高模且更低水渗透性的UHMWPE机织覆膜的可行性。研究结果表明:UHMWPE机织覆膜在周向拉伸、轴向拉伸和顶破等力学性能方面均显著优于PET机织覆膜(p<0.05),其周向拉伸断裂强度约为PET机织覆膜的6.3倍,轴向拉伸断裂强度约为PET机织覆膜的3.2倍,顶破强力约为PET机织覆膜的3.0倍。UHMWPE机织覆膜的水渗透性为(20.358±3.747)mL/(cm²·min),低于PET机织覆膜[(73.397±4.319)mL/(cm²·min)](p<0.05)。可见,UHMWPE机织覆膜具有高强高模及低水渗透性的优势,故基于UHMWPE纱开发腔内隔绝术用支架覆膜是可行的。研究结果为推动新一代覆膜支架产品的开发提供了理论及实践依据。

Abstract

The covered stents have played an irreplaceable role in clinical treatment of aortic aneurysms. Currently, the graft cover in commercial covered stents is primarily made of woven polyethylene terephthalate (PET) materials. Long-term clinical practice has revealed that PET woven graft cover exhibits high water permeability, often requiring subsequent treatment, and cases of graft cover wear and perforation have been occasionally reported. Ultra-high molecular weight polyethylene (UHMWPE) material has been widely used in the field of sports medicine due to its high strength and high modulus. In this study, UHMWPE yarns were introduced to fabricate UHMWPE woven graft cover and PET/UHMWPE woven graft cover, which were then systematically compared and analyzed with PET woven graft cover with the same yarn specifications. The feasibility of developing UHMWPE woven graft cover with high strength and high modulus and lower water permeability was explored. The results showed that, the UHMWPE woven graft cover demonstrated significantly superior mechanical properties compared to the PET woven graft cover in terms of circumferential tensile, axial tensile, and bursting strength (p<0.05). Specifically, its circumferential tensile breaking strength, axial tensile breaking strength, and bursting strength were approximately 6.3 times, 3.2 times, and 3.0 times higher than those of the PET woven graft cover. The water permeability of the UHMWPE woven graft cover was (20.358±3.747)mL/(cm²·min), which was lower than that of the PET graft cover [(73.397±4.319)mL/(cm²·min)](p<0.05). These results indicate that the UHMWPE woven graft cover offers the advantages of high strength and high modulus and low water permeability, so it is feasible to develop graft cover for endovascular surgery based on UHMWPE yarns. The research findings provide theoretical and practical grounds for advancing the development of next-generation covered stent products.

关键词

覆膜支架 / 机织覆膜 / 超高分子量聚乙烯(UHMWPE) / 聚对苯二甲酸乙二醇酯(PET) / 高强高模 / 水渗透性

Key words

covered stent / woven graft cover / UHMWPE / PET / high strength and high modulus / water permeability

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