Influence of Quercetin on Reproductive Performance and Mechanism of Action in Perinatal Sows

摘要

The purpose of this experiment was to investigate the effect and mechanism of quercetin on reproductive performance in perinatal sows.According to the similar principle of parity and body weight,24 perinatal sows were randomly divided into four treatments with six replicates,including normal control and three treatments fed by a basal diet supplemented with 0,0.025%,0.050%,and 0.075% quercetin,respectively.The feeding trial was conducted from 100 days of gestation to 28 days post-partum.Reproductive performance,colostrum composition,serum indexes of antioxidation,inflammation,hormones,and the diversity and relative abundance of fecal microflora were determined in perinatal sows.Compared with the control,quercetin significantly reduced the rate of constipation,serum content of malondialdehyde (MDA),prolactin (PRL),and progesterone (PROG),and significantly increased the content of serum estradiol (E2) and insulin-like growth factor-1 (IGF-1) in colostrum of perinatal sows (P<0.05).Meanwhile,0.025% quercetin significantly increased glutathione (GSH) content in serum (P<0.05),0.050% quercetin significantly reduced the rate of backfat loss (P<0.05),and 0.075% quercetin significantly increased immunoglobulin M (IgM) content in colostrum of perinatal sows (P<0.05).In addition,0.050% and 0.075% quercetin significantly shortened estrus interval (P<0.05) and significantly increased the content of IgA and IgG in colostrum (P<0.05) and dopamine (DA) content in serum of perinatal sows (P<0.05).Quercetin significantly decreased the content of nitric oxide (NO),IL-1β,IL-6,TNF-α,and MCP-1 in serum (P<0.05) and significantly improved microflora abundance and diversity in feces of perinatal sows (P<0.05).In conclusion,dietary supplementation of quercetin reduced oxidative stress and inflammatory responses and regulated intestinal microflora in perinatal sows,thus improved reproductive performance in perinatal sows.Under this experimental condition,the optimal supplementation with dietary quercetin was 0.075% in perinatal sows.

关键词

quercetin / perinatal sows / reproductive performance / anti-oxidation / intestinal microflora