Research Progress on Construction Strategies for Coronavirus Reverse Genetic System

摘要

Coronavirus is an RNA virus that can infect both humans and animals, posing a significant threat to agriculture and public health. Although coronaviruses are highly host-specific, their ability to infect multiple hosts, combined with the structure of their genome, gives them a high probability of genetic recombination and mutation, leading to the creation of novel viruses. In recent years, with the establishment and development of reverse genetic manipulation techniques, substantial technical support has been provided for studying the structure and function of the coronavirus genome, the development of novel vaccines and drugs and the construction of viral expression vectors. This paper briefly described the progress in research on coronaviruses and their reverse genetic system construction strategies, aiming to provide some references for future coronavirus research.

关键词

coronavirus / reverse genetics / research progress