Revelation of GABRG1 as a Novel Prognostic Indicator via Integrated Bioinformatics Analysis in Glioma

摘要

This study investigated the expression characteristics and clinical significance of gamma-aminobutyric acid A(GABAA) receptor subunit gamma1(GABRG1) in glioma by integrating cancer and normal tissue data from multiple databases and combining them with experimental evidence. The research revealed that GABRG1 exhibited low expression levels in glioma, and its low expression was closely associated with unfavorable clinical outcomes. Furthermore, a prognostic model with strong decision-making ability was constructed using multivariate Cox regression analysis, incorporating age, isocitric dehydrogenase(IDH) mutation status, O6-methylguanine-DNA methyltransferase(MGMT) methylation status, World Health Organization(WHO) grade, and GABRG1 expression. Additionally, GABRG1 might be associated with the expression of tumor-associated macrophages and was significantly linked to immune regulatory processes. This study provided a new target for immunotherapy in glioma and offered a novel indicator for predicting and evaluating the clinical prognosis of patients.

关键词

GABRG1 / pan-cancer / glioma / prognosis / nomogram / immune infiltration