To investigate the evolution of spatial characteristics and the driving mechanisms of “One Village, One Product” (OVOP) demonstration villages and towns, 12 batches of OVOP demonstration villages and towns were selected as the research objects. Spatial characterization analysis tools and the optimal parameter geographic detector model were employed to analyze the spatial distribution and the evolution of the driving mechanisms. The findings reveal that: The industrial structure of OVOP demonstration villages and towns has evolved towards prioritizing food security, ensuring an abundant food supply, and fostering deeper integration of industries. The spatial distribution of these villages and towns exhibits a “non-uniform distribution” trend. The east-west distribution shows a “stepped decline” and continues to expand, while the north-south direction displays a “U-shaped” trend that is gradually shrinking. The spatial structure of OVOP demonstration villages and towns is characterized by a “cohesive distribution”, with high-density areas located to the east of the “Hu Huanyong Line”. These areas form a ring of villages and towns, with “E Xiang Gan” as the three core regions, and have evolved from a ring-shaped distribution centered around “Hubei Xianning” as the single core. The global spatial correlation of OVOP demonstration villages and towns is unsignificant; however, locally, a “low-high” aggregation pattern has emerged, with Shanghai as the core. The spatial characteristics of OVOP demonstration villages and towns have shifted from a two-dimensional driving mechanism of “labor-farmland” to a multi-dimensional driving mechanism involving “labor-farmland-capital-technological-demand-safeguards”. Notably, the driving effects of labor and farmland factors have gradually weakened, while the driving effects of capital, technology, and demand have progressively strengthened. Additionally, the role of the “safeguards” factor has evolved from being unsignificant to becoming significant.
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