N⁶-甲基腺嘌呤修饰与皮肤疾病（英文）

N⁶-methyladenosine modification and skin diseases

摘要

目前，N⁶-甲基腺嘌呤（N6-methyladenosine,m⁶A）在肿瘤领域研究较多，但m⁶A与皮肤疾病的研究仍相对滞后。本研究收集PubMed和Web of Science中m⁶A与皮肤疾病相关的研究报道，通过分析其被引用数和期刊的影响因子，发现m⁶A相关研究量明显上升。针对标题和摘要的词频分析发现研究主要与皮肤肿瘤和炎症免疫性疾病相关，以黑色素瘤、银屑病和皮肤发育多见。分析基因表达综合数据库（Gene Expression Omnibus,GEO）中的皮肤疾病转录组数据，发现m⁶A相关基因在鳞状细胞癌和基底细胞癌等4种皮肤肿瘤，以及银屑病和特应性皮炎等多种炎症免疫性疾病中均存在差异表达，并分析了其可能作用机制。本研究从m⁶A与基因表达及m⁶A相关基因具体功能的角度，发现肿瘤与非肿瘤性皮肤病中m⁶A存在异质性等问题，但m⁶A动态修饰对皮肤病关键基因的调控机制并不十分明确，后续需进一步研究。

Abstract

Currently, research on N⁶-methyladenine (m⁶A) is extensive in the field of oncology, while studies involving m⁶A and skin diseases remain relatively limited. Based on existing reports, we searched PubMed and Web of Science for literature related to m⁶A and dermatological conditions. Analysis of citation counts and journal impact factors revealed a significant upward trend in the volume of m⁶A-related research. Term frequency analysis of titles and abstracts indicated that studies mainly focus on skin tumors and inflammatory or immune-related skin diseases, particularly melanoma, psoriasis, and skin development. Transcriptomic data from the Gene Expression Omnibus (GEO) were analyzed, revealing differential expression of m⁶A-related genes in 4 types of skin tumors (including squamous cell carcinoma and basal cell carcinoma) as well as in inflammatory skin diseases such as psoriasis and atopic dermatitis, and potential mechanisms of action were also explored. Findings suggest that m⁶A modifications exhibit heterogeneity between neoplastic and non-neoplastic skin diseases. However, the regulatory mechanisms of m⁶A dynamic modifications on key genes involved in dermatological disorders remain unclear and warrant further investigation.

关键词

皮肤肿瘤 / 皮肤炎症免疫性疾病 / N⁶-甲基腺嘌呤 / 表观遗传学 / 药物开发

Key words

skin tumors / inflammatory and immune-related skin diseases / N⁶-methyladenosine / epigenetics / drug development