以新药开发为导向的药理学硕士研究生培养教学实践研究

摘要

针对当前药理学研究生培养中存在的理论与实践脱节的问题，基于建构主义学习理论，采用情境学习模式，笔者构建了以新药研发为导向的全程教学实践模式，建立了“项目驱动—问题导向—多学科融合”的培养体系，结合公共资源、校企合作项目，将新药研发全流程拆解为靶点验证、化合物优化、药效学、药代动力学等子任务，通过问题驱动和跨学科整合，提升研究生高阶思维能力。通过7年的实践，将药学理论与实践深度融合，提高了研究生科学技能与药学思维能力，为药理学研究生培养模式改革提供理论依据和实践范式。经过教师打分和过程性评价，结果显示学生综合素养得到提升，项目报告完成情况良好。该模式为国家医药产业高质量发展需要的药理学复合型人才培养提供了新的路径。

Abstract

In response to the disconnection between theory and practice in current pharmacology graduate education, and based on constructivist learning theory with a situational learning model, this study established a practice-oriented teaching framework guided by new drug research and development(R&D). A training system characterized by “project-driven, problem-oriented, and multidisciplinary integration” has been established. By aligning with public resources and university-enterprise collaboration projects, the entire new drug R&D process is segmented into sub-tasks such as target validation, compound optimization, pharmacodynamics, and pharmacokinetics. Through problem-driven approaches and interdisciplinary integration, the advanced thinking abilities of graduate students are enhanced. After seven years of implementation, this system has effectively integrated pharmaceutical theory with practice, improved students' scientific skills and pharmacological thinking, and provided theoretical foundations and practical paradigms for reforming pharmacology graduate training. Assessments through faculty scoring and process evaluations indicate a significant improvement in students' comprehensive competencies and satisfactory completion of project reports. This model offers a new pathway for cultivating interdisciplinary pharmacology talents aligned with the high-quality development needs of China’s pharmaceutical industry.

关键词

研究生培养；新药研发导向；药理学

Key words

graduate education; new drug development orientation; pharmacology