维生素D与女性生育力及生殖系统疾病的研究进展

Research advances in the role of vitamin D in female fertility and reproductive system diseases

摘要

维生素D受体在女性生殖器官中广泛表达，维生素D与维生素D受体结合调节体内骨和钙稳态，参与炎症、细胞介导免疫、细胞周期和凋亡等多种信号通路。维生素D对卵泡发育和卵巢储备、子宫内膜容受性有调节作用；维生素D缺乏与多囊卵巢综合征病理进程有关；补充维生素D对预防卵巢早衰、子宫肌瘤、子宫内膜异位症和卵巢癌有重要意义；体内维生素D水平与体外受精结局也有一定相关性。维生素D缺乏是一个主要公共卫生问题，合理补充维生素D，有益于维护女性生殖健康。

Abstract

Vitamin D receptor（VDR） is widely expressed in female reproductive organs，and vitamin D binds with VDR to regulate bone and calcium homeostasis and participate in various signaling pathways such as inflammation，cell-mediated immunity，cell cycle，and apoptosis inside the body. Vitamin D regulates follicular development，ovarian reserve，and endometrial receptivity，and vitamin D deficiency is associated with the pathological process of polycystic ovary syndrome. Vitamin D supplementation is of great significance in preventing premature ovarian failure，uterine myoma，endometriosis，and ovarian cancer. The level of vitamin D inside the body is also associated with the outcome of in vitro fertilization. Vitamin D deficiency is a major public health problem，and reasonable supplementation of vitamin D may help to maintain female reproductive health.

关键词

维生素D / 卵巢储备 / 内膜容受性：多囊卵巢综合征 / 卵巢早衰 / 子宫肌瘤 / 子宫内膜异位症 / 卵巢癌 / 体外受精

Key words

vitamin D / ovarian reserve / endometrial receptivity / polycystic ovarian syndrome / premature ovarian failure / uterine myoma / endometriosis / ovarian cancer / in vitro fertilization

基金资助

国家自然科学基金资助项目(81960273)