活体共聚焦显微镜在不同类型干眼检查中的应用进展

Progress in the application of in vivo confocal microscopy in different types of dry eye examination

摘要

干眼发病机制复杂，各种病因最终都会导致角结膜损伤而引起一系列眼部不适症状，了解干眼患者眼表病理改变对疾病诊治有重要意义。近年来，活体共聚焦显微镜（in vivo confocal microscopy，IVCM）越来越多地用于研究干眼的微观世界。IVCM是一种非侵入性成像工具，可无创实时检查角膜细胞及神经纤维的变化、评估睑板腺等各种结构，为了解干眼的发病机制和细胞组织层面变化提供更好的帮助。本文总结了不同类型干眼在IVCM下的眼表改变，以期进一步了解各类型干眼的病理改变，辅助临床诊疗。

Abstract

The pathogenesis of dry eye is complex，and various etiology will eventually lead to corneal and conjunctival injury and cause a series of eye discomfort symptoms. Understanding the pathological changes of the ocular surface in patients with dry eye is of great significance for the diagnosis and treatment of the disease. In recent years，in vivo confocal microscopy（IVCM） has been increasingly used to study the microscopic world of dry eyes. IVCM is a non-invasive imaging tool that can examine the changes in corneal cells and nerve fibers noninvasively in real time，evaluate various structures such as meibomian glands，and provide better help in understanding the pathogenesis of dry eye and histological changes at the cellular level. This paper summarizes the changes of ocular surface of different types of dry eye under IVCM in order to further understand the pathological changes of each type of dry eye and assist clinical diagnosis and treatment.

关键词

干眼 / 活体共聚焦显微镜 / 眼表 / 组织细胞

Key words

dry eye / in vivo confocal microscopy / ocular surface / histocyte

基金资助

国家自然科学基金面上资助项目(82070935)

重庆市科卫联合医学科研资助项目(2023GDRC004)

重庆医科大学未来医学青年创新团队发展支持计划资助项目(W0185)