硫酸软骨素蛋白多糖在脊髓损伤中的研究进展

Research progress of chondroitin sulfate proteoglycans in spinal cord injury

摘要

硫酸软骨素蛋白多糖（chondroitin sulfate proteoglycans，CSPGs）是中枢神经系统细胞外基质的组成部分，在中枢神经系统发育、正常维持及病理过程中都发挥着关键的作用。脊髓损伤后，损伤部位CSPGs的表达明显上调，这主要源于病变部位活化的星形胶质细胞。CSPGs的上调会限制脊髓损伤部位的轴突再生、传导和再髓鞘化，并且可以促进脊髓损伤中的炎症反应，不利于脊髓损伤后神经功能恢复。因此，抑制CSPGs可能是促进脊髓损伤后轴突再生和功能恢复的有效治疗方法。本文对CSPGs在脊髓损伤中的研究现状进行综述。

Abstract

Chondroitin sulfate proteoglycans（CSPGs） are components of the extracellular matrix of the central nervous system，and play key roles in the development，function maintenance，and pathological process of the central nervous system. After spinal cord injury，the expression of CSPGs at the injury site is significantly upregulated，which is mainly due to activated astrocytes at the lesion site. Upregulation of CSPGs can restrict axon regeneration，conduction，and re-myelination at the site of spinal cord injury，and can promote the inflammatory response in spinal cord injury，which impedes the recovery of nerve function after spinal cord injury. Therefore，inhibition of CSPGs may be an effective treatment to promote axonal regeneration and functional recovery after spinal cord injury. This study reviews the current status of research on CSPGs in spinal cord injury.

关键词

硫酸软骨素蛋白多糖 / 脊髓损伤 / 糖胺聚糖 / 神经修复

Key words

chondroitin sulfate proteoglycan / spinal cord injury / glycosaminoglycan / nerve repair

基金资助

国家自然科学基金资助项目(31960175)