针刺调节神经元程序性细胞死亡的机制研究进展

Research advances in mechanism of acupuncture regulating neuronal programmed cell death

摘要

神经系统疾病的发生和发展过程中常伴随着异常的神经元程序性细胞死亡。针刺作为神经系统疾病的常用防治手段，其调控失衡的神经元程序性细胞死亡的作用值得深入探讨。针刺主要可通过调控神经元凋亡、焦亡、自噬、铁死亡来治疗脑缺血、脑出血、颅脑外伤、脊髓损伤、阿尔茨海默病等疾病。故本文就针刺之于神经元程序性细胞死亡的作用机制进行综述，以期挖掘针刺在多种神经系统疾病治疗过程中的共同生物学机制，为深入开展相关研究提供新思路。

Abstract

The development and progression of nervous system diseases are often accompanied by abnormal neuronal programmed cell death. Acupuncture，as a common means of preventing and treating nervous system diseases，is worthy of in-depth discussion regarding its role in regulating imbalanced neuronal programmed cell death. Acupuncture can treat cerebral ischemia，cerebral hemorrhage，craniocerebral trauma，spinal cord injury，and Alzheimer’s disease mainly by regulating neuronal apoptosis，pyroptosis，autophagy，and ferroptosis. Therefore，this article reviews the role of acupuncture in regulating neuronal programmed cell death，aiming to explore the common biological mechanism of acupuncture in the treatment of various nervous system diseases and provide new ideas for relevant research.

关键词

针刺 / 神经元 / 程序性细胞死亡 / 综述

Key words

acupuncture / neuron / programmed cell death / review

基金资助

国家自然科学基金资助项目(82274652;82074554)