非动脉硬化性脑小血管病的治疗进展

Advances in the treatment of non-arteriosclerotic cerebral small vessel disease

摘要

脑小血管病（cerebral small vessel disease，CSVD）是导致卒中和痴呆的常见原因。而除了常见的小动脉硬化性脑小血管病，非动脉硬化性脑小血管病的防治也不容忽视，目前这类疾病尚缺乏特异的治疗药物，且机制未明、异质性较强，但临床对症治疗方面已有部分证据，在深入挖掘机制的同时也探索出潜在疗法。现旨在对该领域治疗进展予以综述。

Abstract

Cerebral small vessel disease（CSVD） is a common cause of stroke and dementia. Besides the common type of arteriosclerotic CSVD，the prevention and treatment of non-arteriosclerotic arteriosclerotic CSVD should also be taken seriously. At present，there is still a lack of specific therapeutic drugs for such diseases due to unclear mechanisms and strong heterogeneity；however，some clinical evidence has been obtained for symptomatic treatment，and potential therapies are being explored alongside in-depth research on mechanisms. This article reviews the advances in treatment in this field.

关键词

脑小血管病 / 脑淀粉样血管病 / 伴皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病 / 卒中

Key words

cerebral small vessel disease / cerebral amyloid angiopathy / cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy / stroke

基金资助

科技创新2030重大资助项目(2021ZD0201806)

国家自然科学基金资助项目(82271221)

上海市医苑新星杰出青年医师计划资助项目(20224Z0033)