额颞叶痴呆治疗进展

Advances in the treatment of frontotemporal dementia

摘要

额颞叶痴呆（frontotemporal dementia，FTD）是一组临床表型多样，遗传因素复杂，神经病理高度异质的以进行性人格行为改变，执行功能障碍及言语障碍为特征的神经退行性疾病。目前尚无有效治疗方法可以治愈或者逆转FTD进展，临床常采用对症治疗策略改善FTD患者神经精神、运动及认知症状。随着FTD发病机制的深入研究，越来越多靶向FTD突变基因及神经病理的药物正进入临床试验，以实现疾病的早期管理，精准治疗。本文主要就FTD治疗进展进行综述，有助于临床医师了解FTD最新治疗信息，提高FTD疾病管理。

Abstract

Frontotemporal dementia（FTD） is a group of neurodegenerative diseases with diverse clinical phenotypes，complex genetic factors，and highly heterogeneous neuropathology，and it is characterized by progressive changes in personality and behavior，executive dysfunction，and speech and language impairment. Currently，there are no effective treatment methods that can cure FTD or reverse its progression，and in clinical practice，symptomatic treatment strategies are often used to improve the neuropsychiatric，motor，and cognitive symptoms of patients with FTD. With in-depth studies on the pathogenesis of FTD，clinical trials are being conducted for an increasing number of drugs that target the mutant genes and neuropathology of FTD，in order to achieve early management and precise treatment. This article reviews the advances in the treatment of FTD，so as to help clinicians understand the latest information for the treatment of FTD and improve disease management.

关键词

额颞叶痴呆 / 治疗 / 基因靶向 / Tau病理 / 神经调控

Key words

frontotemporal dementia / treatment / gene targeting therapy / Tau pathology / neuromodulation

基金资助

国家自然科学基金资助项目(82271464)