多发性硬化的治疗进展

Advances in the treatment of multiple sclerosis

摘要

多发性硬化（multiple sclerosis，MS）是一种慢性中枢神经系统炎症性脱髓鞘疾病，随着人们对MS发病机制了解的深入，MS的治疗手段也在不断更新。近年来，新上市的疾病修饰治疗（disease-modifying therapy，DMT）药物层出不穷，临床研究显示出良好的疗效及安全性。治疗策略及目标也在更新。本文主要对近年来新上市的DMT药物的作用机制、疗效以及安全性进行综述，此外对治疗策略、治疗目标以及正在研发的新药也做了简要介绍，以期为临床决策的制定提供参考。

Abstract

Multiple sclerosis（MS） is a chronic inflammatory demyelinating disease of the central nervous system. As our understanding of the pathogenesis of MS gradually deepens， the treatment methods for MS are being constantly updated. In recent years，a large number of disease-modifying therapy（DMT） drugs have been introduced，and clinical studies have shown that such drugs have good efficacy and safety. Treatment strategies and goals are also being improved. This article mainly reviews the mechanism of action，efficacy， and safety of the DMT drugs introduced in recent years and briefly introduces treatment strategies，treatment goals，and new drugs under development，in order to provide a reference for clinical decision-making.

关键词

多发性硬化 / 治疗 / 进展 / 疾病修饰治疗

Key words

multiple sclerosis / treatment / advances / disease-modifying therapy

基金资助

国家自然科学基金资助项目(81901229)