抗癫痫发作药物的应用进展

Advances in the application of anti-seizure medications

摘要

癫痫是神经系统中第二大常见疾病，在我国有超过900万的患者。尽管目前已经有超过20种抗癫痫发作药物，仍然有大约1/3的患者对抗癫痫发作药物治疗表现出耐药性。近年来，癫痫治疗领域取得了明显的进展，引入了新的抗癫痫发作药物，为患者提供了更多治疗选择。这些药物不仅在控制癫痫发作方面发挥着作用，而且在减轻药物不良反应和提高患者生活质量方面取得了明显的改善。本文旨在综述近15年来上市的抗癫痫发作药物，以提升临床医师对新上市抗癫痫发作药物的了解，并加深对它们在临床实践中的应用认知水平。

Abstract

Epilepsy ranks second among the common disorders of the nervous system，affecting over 9 million patients in China. Although 20 anti-seizure medications have been developed at present，about one-third of patients still show resistance to anti-seizure medications. In recent years，significant progress has been made in the field of epilepsy treatment，and new anti-seizure medications have been introduced to provide patients with more treatment options. These drugs not only play a role in controlling seizures，but also have achieved significant improvements in reducing drug side-effects and improving the quality of life of patients. This article reviews the anti-seizure medications that have been marketed in the past 15 years，so as to enhance the understanding of newly marketed anti-seizure medications among clinicians and deepen the level of knowledge about their application in clinical practice.

关键词

癫痫 / 难治性癫痫 / 抗癫痫发作药物

Key words

epilepsy / intractable epilepsy / anti-seizure medications

基金资助

国家重点研发计划资助项目(2022YFC2503800)

国家自然科学基金面上资助项目(81971213)