氧化应激在类风湿关节炎中的调控机制及中药干预研究进展

骆美秀; 潘志; 王颖航

doi:10.13406/j.cnki.cyxb.003509

重庆医科大学学报 ›› 2024, Vol. 49 ›› Issue (10) : 1055 -1060. DOI: 10.13406/j.cnki.cyxb.003509

综述

氧化应激在类风湿关节炎中的调控机制及中药干预研究进展

骆美秀 ¹ ,
潘志 ² ,
王颖航 ³

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Research advances in the regulating mechanism of oxidative stress in rheumatoid arthritis and intervention with traditional Chinese medicine

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摘要

类风湿关节炎（rheumatoid arthritis，RA）是一种以慢性、全身免疫性疾病，以侵蚀性关节炎为主要表现，发病机制尚不明确，近年来研究发现RA的发生与氧化应激有关，故氧化应激可能是其发病机制之一。研究表明中药抗氧化防治RA具有多层次、多靶点、安全性高、副作用少等优点。本文基于氧化应激机制对中药防治RA现状进行综述，归纳分析其主要作用机制的相关因子和通路，旨在为其临床研究提供理论支撑并为其基础研究提供参考方向。

Abstract

Rheumatoid arthritis（RA） is a chronic，systemic autoimmune disease，with erosive arthritis as its main manifestation. The pathogenesis of the disease is unclear，but recent studies have found that the development of RA is related to oxidative stress. Therefore，oxidative stress may be one of its pathogenic mechanisms. Studies have shown that traditional Chinese medicine（TCM），as an antioxidative means of preventing and treating RA，has the following advantages：multi-level and multi-target action，a favorable safety profile，and fewer side effects. This article reviews the current status of prevention and treatment of RA with TCM based on the oxidative stress mechanism and summarizes and analyzes the factors and pathways related to its main mechanisms of action. It aims to provide a theoretical basis for clinical research and shed light on the directions for basic research.