miRNA在脓毒症细胞焦亡中的研究进展

Research advances in the role of miRNA in pyroptosis during sepsis

摘要

脓毒症是一种危及生命的器官功能障碍，由宿主对感染反应失调引起的，是重症监护室患者死亡的重要原因之一，近年来，大量研究表明脓毒症的发生发展与细胞焦亡密切相关。miRNA执行多种重要的细胞功能，包括调节细胞周期、凋亡和分化等。最近的研究表明，miRNA在调节细胞焦亡中发挥了重要功能，细胞焦亡是一种与炎症反应相关的程序性细胞死亡，在许多疾病中起着关键作用，miRNA通过直接或间接作用于焦亡相关信号通路的蛋白质参与脓毒症的调控。本文就miRNA在脓毒症细胞焦亡中的调控和功能进行总结，为脓毒症细胞焦亡的研究提供新的研究方向和思路。

Abstract

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection and is an important cause of death in the intensive care unit. In recent years，numerous studies have shown that pyroptosis is closely associated with the development and progression of sepsis，and miRNA perform a variety of important cellular functions，including regulation of cell cycle，apoptosis，and differentiation. Recent studies have shown that miRNA play an important role in regulating pyroptosis，a programmed cell death associated with inflammatory response that plays a key role in many diseases，and miRNA are involved in the regulation of sepsis by acting directly or indirectly on the proteins of pyroptosis-related signaling pathway. This article summarizes the regulatory effect and role of miRNA in pyroptosis during sepsis，so as to provide new research directions and ideas for the research on pyroptosis during sepsis.

关键词

脓毒症 / 细胞焦亡 / miRNA

Key words

sepsis / pyroptosis / miRNA

基金资助

国家自然科学基金面上资助项目(81871608)