脊髓胶质细胞参与慢性内脏痛发病机制研究

Involvement of spinal glial cells in the pathogenesis of chronic visceral pain

摘要

慢性内脏痛（chronic visceral pain，CVP）是由人体内脏器官基础疾病引发的多种疾病的常见症状之一。其原因包括血管机制、机械因素、持续炎症和不明原因的功能机制。虽然其发病机制尚不明确，但近年来越来越多的研究已开始从神经元转向胶质细胞。脊髓胶质细胞，尤其是星形胶质细胞和小胶质细胞在CVP中起重要作用。基于此，本研究对二者在CVP中的作用机制进行阐述，包括细胞因子、趋化因子和神经活性物质的释放以及细胞内信号通路的改变。最后，由于CVP可发生在多种疾病中，针对星形胶质细胞和小胶质细胞为药用靶点治疗疾病有广阔的应用前景。

Abstract

Chronic visceral pain（CVP） is one of the common symptoms of many diseases triggered by underlying diseases in the visceral organs of the human body. Its causes include vascular mechanisms，mechanical factors，persistent inflammation，and unexplained functional mechanisms. Although the pathogenesis is unclear，more and more research has begun to shift from the neuronal aspect to glial cells in recent years. Spinal glial cells，particularly astrocytes and microglial cells，play an essential role in CVP. Based on this，this study elaborated on the mechanisms of action of astrocytes and microglial cells in CVP，including the release of cytokines，chemokines，and neuroactive substances and the alterations in intracellular signaling pathways. Because CVP is widespread in various diseases，drug treatments targeting astrocytes and microglial cells present broad application prospect.

关键词

慢性内脏痛 / 星形胶质细胞 / 小胶质细胞 / 脊髓背角 / 发病机制

Key words

chronic visceral pain / astrocyte / microglial cell / spinal dorsal horn / pathogenesis

基金资助

国家自然科学基金资助项目(82260855)

贵州省基础研究计划（自然科学）资助项目(黔科合基础-ZK[2022]一般495)