利多卡因对不同肿瘤治疗的辅助作用：基础与临床证据

赵家慧; 韩永正; 李民; 刘畅

doi:10.13406/j.cnki.cyxb.003640

重庆医科大学学报 ›› 2025, Vol. 50 ›› Issue (05) : 579 -584. DOI: 10.13406/j.cnki.cyxb.003640

肿瘤精准医学与转化研究

利多卡因对不同肿瘤治疗的辅助作用：基础与临床证据

作者信息 +

Role of lidocaine in assisting the treatment of different types of tumor： basic and clinical evidence

Author information +

文章历史 +

PDF (549K)

摘要

利多卡因作为一种酰胺类局部麻醉药物，围术期广泛用于癌症患者。本文从基础研究和临床研究方面系统总结了利多卡因对临床中常见肿瘤如乳腺癌、胃癌、结肠癌、肺癌肿瘤细胞增殖、侵袭和转移等方面的影响，并综述其在这4种癌症患者围术期治疗的临床应用。探索利多卡因对不同肿瘤的作用机制，并根据不同肿瘤的治疗特点，设计个体化的给药方案或通过新制剂的合成，优化癌症患者围术期治疗策略，将为利多卡因在辅助围术期肿瘤治疗提供理论依据。

Abstract

Lidocaine，as an amide local anesthetic，is widely used in cancer patients in the perioperative period. This article summarizes the effect of lidocaine on cell proliferation，invasion，and metastasis of common tumors in clinical practice based on both basic and clinical studies，including breast cancer，gastric cancer，colon cancer，and lung cancer，and it also reviews the clinical application of lidocaine in the perioperative treatment of patients with these four types of cancer. It is necessary to explore the mechanism of action of lidocaine in various types of cancer，develop individualized administration regimens based on the treatment characteristics of different tumors，and optimize perioperative treatment strategies for cancer patients through novel formulations，which may provide a theoretical basis for lidocaine in assisting tumor therapy in the perioperative period.