自身免疫脑炎的免疫治疗研究进展

陈静; 田仰华

doi:10.13406/j.cnki.cyxb.003645

重庆医科大学学报 ›› 2025, Vol. 50 ›› Issue (02) : 158 -164. DOI: 10.13406/j.cnki.cyxb.003645

综述

自身免疫脑炎的免疫治疗研究进展

陈静 ¹ ,
田仰华 ²

作者信息 +

Research progress in immunotherapy for autoimmune encephalitis

Jing Chen ¹ ,
Yanghua Tian ²

Author information +

文章历史 +

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摘要

自身免疫性脑炎（autoimmune encephalitis，AE）是近年来发现的由自身免疫机制介导的，临床上以癫痫发作、运动障碍、行为改变、情绪障碍、认知障碍、自主神经功能障碍和意识水平改变为特征的中枢神经系统炎症性疾病。AE可依据不同的致病自身抗体分为不同的类型，大部分AE患者对免疫治疗均有反应。早期的规范免疫治疗是良好预后和防止复发的关键。近年来针对不同靶点的免疫治疗成为研究热点，成为AE患者治疗新的选择。本文拟对AE的免疫治疗研究进展进行综述。

Abstract

Autoimmune encephalitis（AE）is the inflammatory disease of the central nervous system that has been found in recent years and is mediated by autoimmune mechanisms，which is clinically characterized by seizures，movement disorders，behavioral changes，emotional disorders，cognitive disorders，autonomic dysfunction，and altered level of consciousness. AE can be classified into different types based on different pathogenic autoantibodies，and most AE patients respond to immunotherapy. Early standard immunotherapy is the key to good prognosis and prevention of recurrence.In recent years，immunotherapy targeting different targets has become a research hotspot and a new choice for the treatment of AE patients. This article aims to review the research progress of immunotherapy for AE.