膀胱癌液体活检的研究进展

Research advances in liquid biopsy for bladder cancer

摘要

膀胱癌是最常见的泌尿系统肿瘤，其治疗依赖准确的检测和长期随访。这两者对于提高患者预后至关重要。目前膀胱癌的诊断与监测的主要手段是膀胱镜检查，但它的侵入性给患者带来了很大的困扰。液体活检是一种非侵入性的生物标志物检测方法，利用体液中的DNA、RNA、蛋白质等生物标志物来获取相关疾病状态。近年来，液体活检在肿瘤无创检测中的作用越来越受到关注，液体活检有希望成为诊断和检测膀胱癌的新方法。

Abstract

Bladder cancer is the most common malignancy of the urinary system，and its treatment relies on accurate detection and long-term monitoring，which are crucial for improving patient’s prognosis. Currently，cystoscopy is the primary method for diagnosing and monitoring bladder cancer，but its invasive nature poses significant discomfort to patients. Liquid biopsy，which non-invasively detects biomarkers such as DNA，RNA，and proteins in body fluids for information no disease status，has gained increasing attention in recent years for its potential in invasive tumor detection. Liquid biopsy holds promise as a novel approach to diagnosing and monitoring bladder cancer.

关键词

液体活检 / 膀胱癌 / 生物标志物 / 循环肿瘤细胞 / 脱氧核糖核酸 / 核糖核酸 / 外泌体 / 蛋白质组

Key words

liquid biopsy / bladder cancer / biomarker / circulating tumor cell / deoxyribonucleic acid / ribonucleic acid / exosome / proteomics

基金资助

国家自然科学基金资助项目(82103298)

湖南省重点领域研发计划资助项目(2023SK2016)