趋化因子及其受体在认知障碍性疾病中的研究进展
赵后雨 , 梁坤 , 于泽源 , 丁伟 , 文宇坤 , 黄建铭 , 方以群
重庆医科大学学报 ›› 2025, Vol. 50 ›› Issue (07) : 920 -925.
趋化因子及其受体在认知障碍性疾病中的研究进展
Research advances in chemokines and their receptors in cognitive disorders
Cognitive impairment is the main clinical manifestation of many nervous system diseases such as stroke,multiple sclerosis,and neurodegeneration,and neuroinflammation is one of the key mechanisms for the onset of cognitive disorders. Chemokines are a class of highly conserved small-molecule secretory proteins that bind to the corresponding chemokine receptors located on cell membrane,activating downstream signaling pathways and playing an important role in cell migration,proliferation,differentiation,and survival. In the central nervous system,chemokines and their receptors are involved in immune response and can exert a certain regulatory effect on neuroinflammation. This article reviews the research advances in chemokines and their receptors in cognitive disorders,in order to provide new insights and targets for the early diagnosis and treatment of related diseases.
趋化因子 / 趋化因子受体 / 神经炎症 / 认知障碍 / 认知障碍性疾病
chemokines / chemokine receptors / neuroinflammation / cognitive impairment / cognitive disorders
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