趋化因子及其受体在认知障碍性疾病中的研究进展

赵后雨; 梁坤; 于泽源; 丁伟; 文宇坤; 黄建铭; 方以群

doi:10.13406/j.cnki.cyxb.003735

重庆医科大学学报 ›› 2025, Vol. 50 ›› Issue (07) : 920 -925. DOI: 10.13406/j.cnki.cyxb.003735

脑科学与神经精神系统疾病前沿

趋化因子及其受体在认知障碍性疾病中的研究进展

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Research advances in chemokines and their receptors in cognitive disorders

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摘要

认知障碍是很多神经系统疾病如脑卒中、多发性硬化、神经退行性疾病等的主要临床表现，神经炎症是认知障碍性疾病发生最重要的机制之一。趋化因子是一类高度保守的小分子分泌蛋白，它们与位于细胞膜上的相应的趋化因子受体结合，激活下游的信号通路，在细胞的移动、增殖、分化和存活中发挥重要作用。在中枢神经系统中，趋化因子及其受体参与免疫反应，对神经炎症具有一定的调控作用。本文将对趋化因子及其受体在认知障碍性疾病中的研究进展进行详细综述，以期为相关疾病的早期诊断及治疗提供新思路和新靶点。

Abstract

Cognitive impairment is the main clinical manifestation of many nervous system diseases such as stroke，multiple sclerosis，and neurodegeneration，and neuroinflammation is one of the key mechanisms for the onset of cognitive disorders. Chemokines are a class of highly conserved small-molecule secretory proteins that bind to the corresponding chemokine receptors located on cell membrane，activating downstream signaling pathways and playing an important role in cell migration，proliferation，differentiation，and survival. In the central nervous system，chemokines and their receptors are involved in immune response and can exert a certain regulatory effect on neuroinflammation. This article reviews the research advances in chemokines and their receptors in cognitive disorders，in order to provide new insights and targets for the early diagnosis and treatment of related diseases.