CD8⁺T细胞在子宫内膜癌肿瘤微环境中作用的研究进展

Research advances in the role of CD8⁺ T cells in the tumor microenvironment of endometrial cancer

摘要

子宫内膜癌（endometrial cancer，EC）是女性生殖系统常见的恶性肿瘤之一，传统的治疗手段如手术、放化疗等效果有限。CD8⁺T细胞是肿瘤微环境（tumor microenvironment，TME）中的主要效应细胞，也是近年兴起的免疫治疗的主要靶细胞之一。本文简述了CD8⁺T细胞通过穿孔素-颗粒酶途径、FAS通路及分泌细胞因子3种途径在TME中发挥细胞毒性作用，且EC患者外周环境的变化可能影响CD8⁺T细胞的功能；同时总结了以CD8⁺T细胞作为EC治疗靶点的应用，以期为临床治疗提供思路。

Abstract

Endometrial cancer（EC） is one of the common malignant tumors of the female reproductive system，and the conventional treatment methods including surgery and radiochemotherapy have a limited therapeutic effect. CD8⁺ T cells are the main effector cells in tumor microenvironment（TME） and are also the main target cells for immunotherapy that have emerged in recent years. This article briefly elaborates on the cytotoxic effect of CD8⁺T cells in TME through the three pathways of the perforin-granzyme pathway，the FAS pathway，and the secretion of cytokines，and the changes in the peripheral environment of patients with EC may affect the functions of CD8⁺ T cells. This article also summarizes the application of CD8⁺ T cells as the targets for EC treatment，in order to provide new ideas for clinical treatment.

关键词

CD8⁺T细胞 / 子宫内膜癌 / 肿瘤微环境

Key words

CD8⁺ T cells / endometrial cancer / tumor environment

基金资助

国家自然科学基金资助项目(82372284;82373826)