糖尿病周围神经病变诊断和治疗的研究进展

李震寒; 陈中沛; 余晓霞

doi:10.13406/j.cnki.cyxb.003772

重庆医科大学学报 ›› 2025, Vol. 50 ›› Issue (05) : 574 -578. DOI: 10.13406/j.cnki.cyxb.003772

内分泌调控与代谢疾病

糖尿病周围神经病变诊断和治疗的研究进展

作者信息 +

Advances in the diagnosis and treatment of diabetic peripheral neuropathy

Author information +

文章历史 +

PDF (556K)

摘要

随着人口老龄化的加剧，糖尿病发病率持续攀升，而约半数的糖尿病患者会发生糖尿病周围神经病变（diabetic peripheral neuropathy，DPN）。DPN主要表现为从远端到近端的周围神经功能丧失，其症状主要包括弥漫性和持续性的自发性难治性疼痛，是糖尿病最常见的慢性并发症之一。DPN病死率高，预后差，且发病机制尚不完全清楚。目前DPN临床治疗的重点是缓解其临床症状，以及控制血糖和降低心血管不良事件的风险。本文探讨了DPN的发病机制、诊断和治疗方法，总结了相关研究的最新进展，为DPN临床诊断和治疗提供新的思路。

Abstract

As the population ages，the incidence of diabetes continues to climb. Diabetic peripheral neuropathy （DPN） occurs in about half of diabetic patients. DPN is characterized by the loss of peripheral nerve function from distal to proximal，with the main symptom of diffuse and persistent spontaneous intractable pain，which is one of the most common chronic complications of diabetes. DPN has a high mortality rate and poor prognosis，and the pathogenesis is not fully clear. The current focus of clinical treatment for DPN is to alleviate the clinical symptoms，as well as to control blood glucose and reduce the risk of adverse cardiovascular events. This study investigated the pathogenesis，diagnosis，and treatment of DPN and summarized the latest research progress to provide new ideas for clinical diagnosis and treatment of DPN.