血液非靶向代谢组学在研究脊髓损伤后膀胱功能改变的可行性分析

康寅博; 双卫兵

doi:10.13406/j.cnki.cyxb.003805

重庆医科大学学报 ›› 2025, Vol. 50 ›› Issue (04) : 432 -436. DOI: 10.13406/j.cnki.cyxb.003805

下尿路神经性排尿功能障碍及盆底功能修复专题

血液非靶向代谢组学在研究脊髓损伤后膀胱功能改变的可行性分析

康寅博 ,
双卫兵

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Feasibility of blood untargeted metabolomics in studying bladder function changes after spinal cord injury

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摘要

创伤性脊髓损伤和膀胱损伤都是常见外科损伤，代谢组学研究的是生物体特定部分中所有代谢产物的定性和定量分析，以及这些代谢产物在外界影响或疾病状态下变化规律的科学。该技术主要是对体液、细胞和组织中的代谢物进行分析，目前已成为发现生物标志物的重要手段之一，脊髓损伤的病理生理学很复杂，血液代谢组学可以对血液中物质进行差异性分析，通过血液代谢组学进行探索发病过程及机制具有巨大研究价值。

Abstract

Traumatic spinal cord injury and bladder injury are both common surgical injuries. Metabolomics studies are the qualitative and quantitative analysis of all metabolites in a specific part of the organism and the science of the changing laws of these metabolites under external influences or disease conditions. The technology is mainly to analyze the metabolites in body fluids，cells，and tissues，and has become one of the important means for discovering biomarkers. The psychopathology of spinal cord injury is very complex. Blood metabolomics allows differential analysis of the substances in blood and has great value for exploring the disease process and mechanism.