重症肺炎合并脓毒症休克早期诊断的研究进展

Research progress on early diagnosis of severe pneumonia combined with septic shock

摘要

重症肺炎是脓毒症休克的主要诱因。重症肺炎可以触发全身炎症反应,导致广泛的内皮功能障碍和血管扩张,最终导致脓毒症休克。脓毒症休克是重症监护病房中导致患者死亡的主要原因之一,因此,针对该疾病进行有效的早期诊断显得尤为重要。然而,目前对于重症肺炎合并脓毒症休克的早期诊断仍缺乏有效的金标准,尚无兼具高敏感度和特异度的单一生物标志物可供临床使用。本文对上述新型标志物及多指标联合策略的早期诊断价值进行综述,旨在为临床治疗提供新的思路。

Abstract

Severe pneumonia is the main cause of septic shock. Severe pneumonia can trigger systemic inflammatory responses,leading to extensive endothelial dysfunction and vascular dilation,ultimately resulting in septic shock. Septic shock is one of the main causes of patient death in intensive care units,therefore,effective early diagnosis of this disease is particularly important. However,there is still a lack of effective gold standards for early diagnosis of severe pneumonia complicated with septic shock,and there are no highly sensitive and specific single biomarkers available for use. This review summarizes the early diagnostic value of novel biomarkers and muti-indicator combination strategies,aiming to provide new ideas for clinical treatment.

关键词

重症肺炎 / 脓毒症休克 / 早期诊断

Key words

Severe pneumonia / Septic shock / Early diagnosis

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基金资助

济宁市重点研发项目(2023YXNS183)