Life-cycle cost (LCC) analysis of railway bridges can provide more reasonable data support for the selection of bridge design schemes. Taking a high-speed railway bridge as an example and in combination with the bridge span requirements, two design schemes were proposed: cable-stiffened continuous rigid-frame superstructure and an arch-stiffened continuous rigid-frame superstructure. Based on the budgetary estimate, the construction costs for both design schemes were calculated. Accounting for the uncertainties inherent in the time-variant performance degradation of cables, a time-variant model for the calculation of the failure probability of the cable and hanger system during bridge operation was established to determine the optimal timing for cable and hanger replacement. For maintenance activities such as cable replacement and arch rib painting, the operation and maintenance costs of the two design schemes were calculated and the influence of the time value of capital on the operation and maintenance costs was analyzed. Addressing the uncertainties present in both the cost data and the calculation model, the distribution ranges of the LCCs for the two design schemes were presented. The results indicate that the costs of inspection, maintenance, and reinforcement during bridge operation significantly impact life-cycle costs. The life-cycle cost analysis method proposed in this study can effectively predict the maintenance timing during the operation period, providing support for accurate estimation of life-cycle costs. In the process of life-cycle cost analysis, it is necessary to fully consider the uncertainties during construction and operation, as well as the time value of costs. For the bridge in the case, from the perspective of life-cycle costs, the cable-stiffened continuous rigid-frame bridge design scheme has greater advantages, offering a reference for the selection of design schemes for similar long-span railway bridges.
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