分子网络在中药成分鉴定中的应用进展

Progress in the Application of Molecular Networks for the Identification of Traditional Chinese Medicine Components

摘要

传统中药是中华民族传承千年的瑰宝，其“多成分、多靶点”的特点导致其药效物质基础研究存在不足。分子网络可通过算法将结构相似的一类化合物连接形成网络图。近年来，研究人员已将分子网络应用于中药药效物质基础研究，用于表征中药及其复方的化学成分。综述分子网络在中药及其复方成分表征中的研究现状，以期为未来中药药效物质基础研究提供理论依据和研究方向。

Abstract

Traditional Chinese medicines (TCMs), a treasure inherited by the Chinese nation for thousands of years, are characterized by “multi-component and multi-target”, which makes the research on the material basis of their efficacy insufficient. Molecular networks can be used to connect structurally similar compounds of the same class through algorithms to form network diagrams. In recent years, some researchers have applied molecular networks to the basic research on the material basis of the efficacy of TCMs and the characterization of the chemical components of TCMs and their compound prescriptions. This paper reviews the current research status of molecular networks in the characterization of TCM components and their compound prescriptions, so as to provide the theoretical basis and directions for future research on the material basis of the efficacy of TCMs.

关键词

中药 / 分子网络 / 成分表征

Key words

traditional Chinese medicine / molecular network / component characterization

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基金资助

国家自然科学基金资助项目(82174013)

国家自然科学基金资助项目(82470448)