维生素AD滴剂联合蛋白琥珀酸铁防治早产儿轻中度贫血的临床效果分析

Clinical Effect Analysis of Vitamin AD Drops Combined with Iron Proteinsuccinylate for the Prevention and Treatment of Mild to Moderate Anemia in Premature Infants

摘要

目的 探讨维生素AD滴剂联合蛋白琥珀酸铁在防治早产儿轻中度贫血中的临床效果及安全性。方法 选取2023年1月至2024年6月杭州市妇产科医院收治的80例贫血早产儿为研究对象，根据贫血程度分为轻度贫血组和中度贫血组，每组各40例。所有患儿均予以维生素AD滴剂和蛋白琥珀酸铁联合治疗。观察并比较2组的临床效果，以及治疗前后的贫血相关指标[血红蛋白（hemoglobin，Hb）、血清铁（serum iron，SI）、血清铁蛋白（serum ferritin，SF）、网织红细胞计数（reticulocyte count，Rtc）]和肝肾功能相关指标[丙氨酸氨基转移酶（alanine amino-transferase，ALT）、天冬氨酸氨基转移酶（aspartate transferase，AST）、肌酐（creatinine，Cr）、血尿素氮（blood urea nitrogen，BUN）]。结果 轻度贫血组治疗总有效率显著高于中度贫血组（P< 0.05）；治疗4周后，2组Hb、SI、SF及Rtc水平较治疗前显著升高（ P< 0.05），且轻度贫血组上述指标水平显著高于中度贫血组（ P< 0.05）；治疗4周后，2组ALT、AST、Cr、BUN水平与治疗前相比，差异无统计学意义（ P> 0.05）。结论 维生素AD滴剂联合蛋白琥珀酸铁治疗早产儿轻度贫血的效果更为显著，可有效改善轻、中度贫血早产儿的贫血状况，且安全性较高，对患儿肝肾功能无明显损害。

Abstract

Objective To investigate the clinical efficacy and safety of vitamin AD drops combined with iron proteinsuccinylate in the prevention and treatment of mild to moderate anemia in premature infants. Methods Eighty premature infants with anemia who were admitted to Hangzhou Obstetrics and Gynecology Hospital from January 2023 to June 2024 were enrolled. They were divided into a mild anemia group and a moderate anemia group according to the severity of anemia, with 40 infants in each group. All infants were treated with a combination of vitamin AD drops and iron proteinsuccinylate. The clinical efficacy, anemia-related indicators [hemoglobin (Hb), serum iron (SI), serum ferritin (SF), reticulocyte count (Rtc)], liver and kidney function indicators [alanine amino-transferase (ALT), aspartate transferase (AST), creatinine (Cr), blood urea nitrogen (BUN)] before and after treatment were observed and compared between the groups.Results The total effective rate in the mild anemia group was significantly higher than that in the moderate anemia group (P< 0.05). After 4 weeks of treatment, the levels of Hb, SI, SF and Rtc in both groups were significantly higher than baseline ( P< 0.05). Moreover, the above indicators in the mild anemia group were higher than those in the moderate anemia group ( P< 0.05). After 4 weeks of treatment, there were no statistically significant differences in the levels of ALT, AST, Cr and BUN compared with baseline in either group ( P> 0.05). Conclusion The combination of vitamin AD drops and iron proteinsuccinylate is more effective in the treatment of premature infants with mild anemia. It can effectively improve the anemia status of premature infants with mild to moderate anemia, and has a favorable safety profile without obvious damage to liver and kidney function.

关键词

维生素AD滴剂 / 蛋白琥珀酸铁 / 早产儿 / 贫血 / 临床疗效

Key words

vitamin AD drop / iron proteinsuccinylate / premature infant / anemia / clinical efficacy

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基金资助

杭州市医药卫生科技项目(A20240464)