环泊酚与丙泊酚用于脑肿瘤切除术麻醉对脑氧代谢及不良反应的影响

Comparison of the Effects of Ciprofol versus Propofol on Cerebral Oxygen Metabolism and Adverse Reactions in Patients Undergoing Brain Tumor Resection

摘要

目的 探讨环泊酚与丙泊酚在脑肿瘤切除术患者麻醉中对脑氧代谢及不良反应的影响。方法 选取2022年3月至2024年2月广州医科大学附属脑科医院收治的脑肿瘤切除术患者作为研究对象。依据预先制定的纳入与排除标准，最终纳入120例患者。根据患者术中实际应用的麻醉维持药物进行回顾性分组，将采用环泊酚维持麻醉的60例患者纳入环泊酚组，采用丙泊酚维持麻醉的60例患者纳入丙泊酚组。比较2组术前（T0）、术后24 h（T1）、术后72 h（T2）的脑氧代谢指标[颈内静脉血氧饱和度（jugular venous bulb oxygen saturation，SjvO₂）、脑氧摄取率（cerebral oxygen extraction rate，CERO₂）]、简易精神状态检查量表（Mini-Mental State Examination，MMSE）评分，并统计不良反应。结果 环泊酚组T1、T2时SjvO₂、CERO₂及MMSE评分均高于丙泊酚组（P< 0.05）；环泊酚组在T1时不良反应总发生率低于丙泊酚组（ P< 0.05）。结论 环泊酚可改善脑肿瘤切除术患者脑氧代谢，提高术后认知功能，降低不良反应发生率。

Abstract

Objective To investigate the effects of ciprofol versus propofol on cerebral oxygen metabolism and adverse reactions in patients undergoing brain tumor resection. Methods Patients who underwent brain tumor resection surgery in the Affiliated Brain Hospital of Guangzhou Medical University from March 2022 to February 2024 were selected as the research subjects. Based on pre established inclusion and exclusion criteria，120 patients were included，finally. Retrospective grouping was conducted based on the actual use of anesthesia maintenance drugs in patients during surgery. 60 patients who received maintenance anesthesia with cyclosporine were included in the cyclosporine group, and 60 patients who received maintenance anesthesia with propofol were included in the propofol group. The cerebral oxygen metabolism indexes [jugular venous bulb oxygen saturation (SjvO₂), cerebral oxygen extraction rate (CERO₂)] and Mini-Mental State Examination (MMSE) scores were compared between the two groups preoperatively (T0), 24 h postoperatively (T1), and 72 h postoperatively (T2). The incidence of adverse reactions was also recorded.Results The SjvO₂, CERO₂ and MMSE scores at T1 and T2 in the ciprofol group were all higher than those in the propofol group (P< 0.05); besides, the total incidence of adverse reactions at T1 in the ciprofol group was significantly lower than that in the propofol group ( P< 0.05). Conclusion Ciprofol can ameliorate cerebral oxygen metabolism, improve postoperative cognitive function in patients undergoing brain tumor resection, and reduce the incidence of adverse reactions.

关键词

环泊酚 / 丙泊酚 / 脑肿瘤切除术 / 脑氧代谢 / 认知功能

Key words

ciprofol / propofol / brain tumor resection / cerebral oxygen metabolism / cognitive function

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