血清NT-proBNP、sLOX-1、HDAC3水平联合检测对急性心肌梗死患者疾病转归的预测价值

Predictive Value of Combined Detection of Serum NT-proBNP, sLOX-1 and HDAC3 Levels in Patients with Acute Myocardial Infarction

摘要

目的 探讨血清N末端脑利钠肽原（NT-proBNP）、可溶性凝集素样氧化型低密度脂蛋白受体-1（sLOX-1）、组蛋白去乙酰化酶3（HDAC3）水平联合检测对急性心肌梗死（AMI）患者疾病转归的预测价值。方法 回顾性选取开封市第三人民医院2021年11月~2024年2月收治的AMI患者为研究对象（n=155）,根据患者疾病转归情况分为好转组（n=118）、恶化组（n=37）。对比2组入院时及术后6 h血清NT-proBNP、sLOX-1、HDAC3水平,并分析其相关性及预测价值,分析其不同水平患者发生疾病恶化的危险度。结果 恶化组入院时、术后6 h血清NT-proBNP、sLOX-1、HDAC3显著高于好转组（P<0.05）;入院时、术后6 h血清NT-proBNP、sLOX-1、HDAC3水平均与患者疾病转归呈正相关（P<0.05）;入院时、术后6 h血清NT-proBNP、sLOX-1、HDAC3水平联合预测转归不良的AUC分别0.895、0.928,均高于各指标单独预测（P<0.05）;入院时、术后6 h时血清NT-proBNP、sLOX-1、HDAC3高水平患者发生预后不良的危险度是低水平4~10倍（P<0.05）。结论 AMI患者血清NT-proBNP、sLOX-1、HDAC3水平变化可作为临床介入治疗后评估疾病转归的有效预测因子,可辅助临床评估疾病转归情况。

Abstract

Objective To investigate the predictive value of serum N-terminal brain natriuretic peptide (NT-proBNP), soluble lectin like oxidized low density lipoprotein receptor-1 (sLOX-1) and histone deacetylase 3 (HDAC3) levels combined in patients with acute myocardial infarction (AMI). Methods AMI patients admitted to the Third People's Hospital of Kaifeng City from November 2021 to February 2024 were retrospective selected as the research subjects (n=155), and divided into improvement group (n=118) and deterioration group (n=37) according to their disease outcomes. Serum levels of NT-proBNP, sLOX-1 and HDAC3 were compared between the two groups at admission and 6h after operation, and their correlation and predictive value were analyzed, and the risk of disease deterioration was analyzed in patients with different levels. Results Serum NT-proBNP, sLOX-1 and HDAC3 in the worsening group were significantly higher than those in the improving group at admission and 6h after operation (P<0.05). Serum NT-proBNP, sLOX-1 and HDAC3 levels at admission and 6h after surgery were positively correlated with the disease outcome of patients (P<0.05). The AUC of the combined prediction of serum NT-proBNP, sLOX-1 and HDAC3 levels at admission and 6h after surgery was 0.895 and 0.928, respectively, which were higher than those predicted by each index alone (P<0.05). The risk of poor prognosis in patients with high levels of serum NT-proBNP, sLOX-1 and HDAC3 at admission and 6h after surgery was 4 to 10 times that of patients with low levels (P<0.05). Conclusion The changes in serum levels of NT-proBNP, sLOX-1, and HDAC3 in AMI patients can serve as effective predictors for evaluating disease outcomes after clinical intervention, and can assist in the clinical assessment of disease outcome.

关键词

NT-proBNP / sLOX-1 / HDAC3 / 急性心肌梗死

Key words

NT-proBNP / sLOX-1 / HDAC3 / Acute myocardial infarction

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