碳基双原子纳米酶的制备与生物应用研究进展

Progress in the preparation and biological applications of carbon-based dual-atom nanozymes

摘要

碳基双原子纳米酶（dual-atom nanozymes，DAzymes）以其高度可控的原子构型和优异的电子结构调节能力，成为纳米酶领域的研究热点。本综述系统梳理了碳基DAzymes的主要制备方法并进行优势比较，围绕生物医学应用场景，总结了碳基DAzymes的功能优势与应用效果，展望了其在数据驱动设计、多功能集成及临床转化方向的未来发展趋势，旨在为基于碳材料的DAzymes理性设计与应用拓展提供线索。

Abstract

Carbon-based dual-atom nanozymes (DAzymes) have emerged as a research hotspot in the field of nanozymes due to their highly controllable atomic configurations and superior electronic structure regulation capabilities. This paper systematically reviews the primary preparation methods for carbon-based DAzymes and compares their advantages. Centering on biomedical application scenarios, it also summarizes the functional advantages and application performances of carbon-based DAzymes. Finally, it outlines the future development trends in data-driven design, multifunctional integration, and clinical translation, aiming to provide insights for the rational design and application expansion of carbon-based DAzymes.

关键词

双原子纳米酶 / 碳基载体 / 制备 / 肿瘤微环境 / 生物应用 / 肿瘤催化治疗 / 抗菌治疗 / 生物传感

Key words

dual-atom nanozymes / carbon-based carriers / preparation / tumor microenvironment / biological applications / tumor catalytic therapy / antibacterial therapy / biosensing

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基金资助

广西壮族自治区科技计划项目(桂科 AD25069077)