白头翁五环三萜皂苷药理作用研究进展

Research progress on the pharmacological effects of pentacyclic triterpenoid saponins from Pulsatilla chinensis

摘要

白头翁三萜皂苷是从中药白头翁中提取的一类皂苷化合物,其苷元主要为齐墩果烷型和羽扇豆烷型的五环三萜。主要活性成分包括白头翁皂苷A、A3、B4、B5和D等。药理研究表明,白头翁三萜皂苷具有广泛的生物活性,包括抗肿瘤、抗炎、抗氧化、免疫调节,以及增强肿瘤细胞放射敏感性等作用。本文综述了白头翁三萜皂苷的化学成分及其药理作用,为其深入研究和潜在药物开发提供理论依据。

Abstract

Triterpene saponins from Pulsatilla chinensis are a class of saponin compounds isolated from the traditional Chinese medicinal herb Pulsatilla. They are classified as pentacyclic triterpene saponins, possessing oleanane- and lupane-type aglycone. The principal active constituents include several representative saponins, such as Pulsatilla saponin A, A3, B4, B5, and D. Pharmacological studies have revealed that these triterpene saponins exhibit a broad spectrum of biological activities, including anti-tumor, anti-inflammatory, antioxidant, and immunomodulatory effects, as well as the ability to enhance tumor cell radiosensitivity. This review summarizes their chemical constituents and pharmacological activities, providing a theoretical basis for further research and potential therapeutic development.

关键词

白头翁 / 三萜皂苷 / 抗炎 / 抗肿瘤 / 药理作用

Key words

Pulsatilla chinensis / triterpene saponins / anti-inflammatory / antineoplastic / pharmacological activity

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基金资助

国家自然科学基金资助项目(82160663)

江西省自然科学基金资助项目(20232ACB216016)

江西省自然科学基金资助项目(20232BCJ22054)

江西中医药大学校级科技创新团队发展计划项目(CXTD22001)