类风湿关节炎患者海分枝杆菌感染误诊为疾病活动1例报告并文献复习

Mycobacterium marinum infection in a rheumatoid arthritis patient misdiagnosed as disease activity：a case report and literature review

关键词

海分枝杆菌 / 类风湿关节炎 / 免疫抑制 / 多学科诊疗

Key words

Mycobacterium marinum / rheumatoid arthritis / immunosuppression / multidisciplinary treatment

参考文献

[1] NOGUEIRA L B, GARCIA C N, COSTA M S C D, et al. Non—tuberculous cutaneous mycobacterioses[J]. An Bras Dermatol, 2021, 96(5):527-538.

[2] RICCARDI N, ANTONELLO R M, CANETTI D, et al. An octopus gift: Mycobacterium marinum multiple skin lesions[J]. Infection, 2022, 50(6):1631-1632.

[3] GRANOZZI B, CASARINI M, RICCARDI N, et al. Seventeen cases of Mycobacterium marinum infection in italy: a multicenter retrospective study[J]. Diagn Microbiol Infect Dis, 2025, 111(3):116656.

[4] YAO Q H, ZHI H L, XIA X J, et al. Primary cutaneous infections with non—tuberculous mycobacteria: a report of 6 cases[J]. BMC Infect Dis, 2024, 24(1):1231.

[5] DAI N, ZHAO Y Q, WU W J, et al. Multidisciplinary approach improves eradication rate and safety in refractory Helicobacterpylori infection[J]. Clin Transl Gastroenterol, 2025, 16(2):e00804.

[6] LEAL I, ROMÃO V C, MANO S, et al. A non—infectious uveitis multidisciplinary clinic in a tertiary referral center: clinical impact and added value[J]. J Multidiscip Healthc, 2021, 14:695-704.

[7] WEI Y, ZHANG J C, XIN X L, et al. Identification of Mycobacterium marinum in subcutaneous abscesses of an infected patient's foot[J]. J Infect Dev Ctries, 2024, 18(11):1787-1792.

[8] 张帆, 刘红, 暴芳芳, 等. 鱼刺伤肉芽肿10例临床分析[J]. 中国麻风皮肤病杂志, 2021, 37(7): 428-432.

[9] ZHANG F, LIU H, BAO F F, et al. Clinical analysis of 10 cases of granulomas caused by fish bone injuries[J]. China Journal of Leprosy and Skin Diseases, 2021, 37(7): 428-432.

[10] WANG Z H, SUN X R, LIN Y L, et al. Stealth in non—tuberculous mycobacteria: clever challengers to the immune system[J]. Microbiol Res, 2025, 292:128039.

[11] GANESHALINGAM S, WILSON N J, CICIRIELLO S, et al. Cellular interactions in maintaining an inflammatory microenvironment in rheumatoid arthritis[J]. Mol Immunol, 2025, 184:112-122.

[12] CHENG W H, DU C Y, ZHANG S S, et al. Advances in therapeutic strategies against Mycobacterium marinum infection[J]. Expert Rev Anti Infect Ther, 2026, 24(3):355-362.

[13] LI S L, XING Y. A case of Mycobacterium marinum infection in the middle finger of the left hand[J]. Clin Lab, 2025, 71(5/2025):939-943.

[14] MABONI G, PRAKASH N, MOREIRA M A S. Review of methods for detection and characterization of non—tuberculous Mycobacteria in aquatic organisms[J]. J Vet Diagn Invest, 2024, 36(3):299-311.

[15] TAN D Y, HAN J F, SUN Q Z, et al. Application of multiplex fluorescence polymerase chain reaction for detecting pathogenic bacteria in sputum samples from patients with lower respiratory tract infection[J]. Infect Drug Resist, 2023, 16:6999-7005.

[16] WANG L L, CHEN Y, WANG Q Q, et al. Comparison of molecular testing methods for diagnosing non—tuberculous mycobacterial infections[J]. Eur J Clin Microbiol Infect Dis, 2025, 44(1):109-116.

[17] MEYBECK A, TETART M, BACLET V, et al. A disseminated Mycobacterium marinum infection in a renal transplant HIV—infected patient successfully treated with a bedaquiline—containing antimycobacterial treatment: a case report[J]. Int J Infect Dis, 2021, 107:176-178.

[18] 杨燕, 曾谊. 非结核分枝杆菌肺病170例回顾性分析[J]. 南京医科大学学报（自然科学版）, 2021, 41(7): 1058-1062.

[19] YANG Y, ZENG Y. A Retrospective analysis of 170 cases of nontuberculous mycobacterial lung disease[J]. Journal of Nanjing Medical University (Natural Sciences), 2021, 41(7): 1058-1062.

[20] STRASZEWSKI A, TROYER S, BOYER M I, et al. Utility of routine histopathologic and culture analysis in wrist tenosynovectomy[J]. J Hand Surg Am, 2026, 51(5):576.

[21] SUHLING M, DUTT A, COOK O, et al. Disseminated Mycobacterium marinum presenting as bursitis in a patient with psoriatic arthritis on adalimumab[J]. JAAD Case Rep, 2026, 67:55-58.

[22] FEISCHEN M, JORDAN S, KALSDORF B, et al. A case of complicated Mycobacterium marinum infection—“nihil nocere” in differential diagnostic and therapy[J]. Dtsch Med Wochenschr, 2025, 150(17):1046-1049.

[23] THANOU—STAVRAKI A, SAWALHA A H, CROWSON A N, et al. Noodling and Mycobacterium marinum infection mimicking seronegative rheumatoid arthritis complicated by anti—tumor necrosis factor α therapy[J]. Arthritis Care Res, 2011, 63(1):160-164.

[24] MACEK P, BODNAROVA M, ZAVADA J, et al. Mycobacterium marinum epididymoorchitis: case report and literature review[J]. Urol Int, 2011, 87(1):120-124.

[25] FURER V, FRANKS A G, MAGRO C M, et al. Musculoskeletal ultrasound prompts a rare diagnosis of Mycobacterium marinum infection[J]. Scand J Rheumatol, 2012, 41(4):316-318.

[26] SLANY M, JEZEK P, BODNAROVA M. Fish tank granuloma caused by Mycobacterium marinum in two aquarists: two case reports[J]. Biomed Res Int, 2013, 2013:161329.

[27] FLONDELL M, ORNSTEIN K, BJÖRKMAN A. Invasive Mycobacterium marinum infection of the hand[J]. J Plast Surg Hand Surg, 2013, 47(6):532-534.

[28] PAPATHEMELI D, FRANKE I, BONNEKOH B, et al. Explosive generalization of nodular vasculitis— Mycobacterium marinum challenges the paradigm[J]. J Eur Acad Dermatol Venereol, 2016, 30(12):189-191.

[29] LATA C J, EDGAR K, VAUGHAN S. Clinical implications for the timely diagnosis of Mycobacterium marinum in the age of biologic therapy: a case report and review of the literature[J]. Case Rep Infect Dis, 2017, 2017:5274302.

[30] SHAHRIARI N, LACHANCE A, SLOAN B, et al. Mycobacterium marinum infection masquerading as inflammatory arthropathy[J]. J Am Acad Dermatol, 2019, 81(4):AB243.

[31] SCHUBERT N, SCHILL T, PLÜß M, et al. Flare or foe?— Mycobacterium marinum infection mimicking rheumatoid arthritis tenosynovitis: case report and literature review[J]. BMC Rheumatol, 2020, 4:11.

[32] JOYO Y, YASUMA S, USAMI T, et al. Nontuberculous mycobacteriosis oligoarthritis of the right hand misdiagnosed as rheumatoid arthritis: a case report[J]. Mod Rheumatol Case Rep, 2023, 8(1):16-20.

基金资助

国家自然科学基金(82272544)