m6A修饰调控细胞自噬参与雄性生殖疾病研究进展

Research Progress of m6A Modification Regulating Autophagy in Male Reproductive Diseases

摘要

N6-甲基腺苷(N6-methyladenosine, m6A)修饰是在腺苷核苷酸N6位置上发生的甲基化, 在多种RNA代谢过程如mRNA剪接、翻译、运输、降解中发挥关键作用, 进而对各种生命过程产生广泛影响。细胞自噬是真核细胞在自噬相关基因的调控下通过溶酶体对自身细胞质蛋白质和受损细胞器进行降解的过程。本文总结了m6A修饰调控细胞自噬在雄性生殖疾病发生发展过程中的研究进展, 旨在为今后m6A修饰调节自噬水平在雄性生殖中的调控机理研究提供参考资料, 为雄性生殖疾病的治疗策略提供新方向。

Abstract

N6-Methyladenosine (m6A) modification is methylation of adenosine nucleotides at the N6 position in RNA molecules. It plays a pivotal role in various pathways of RNA metabolism such as mRNA splicing, translation, transportation, and degradation, widely affecting life processes. Autophagy is a natural process in which eukaryotic cells use lysosomes to degrade cytoplasmic proteins and damaged organelles under the regu-lation of autophagy-related genes. Herein, the research progress of m6A modification in regulating autophagy in the occurrence and development of male reproductive diseases was summarized. It aimed to provide refe-rence materials for studing the regulatory mechanisms of male reproduction through autophagy level regula-tion by m6A modification, and offer novel therapeutic strategies for treatment of male reproductive diseases.

关键词

N6-甲基腺苷(m6A)修饰 / RNA修饰 / 细胞自噬 / 雄性生殖疾病 / 男性不育

Key words

N6-methyladenosine (m6A) modification / RNA modification / autophagy / male reproductive disease / male infertility