帕金森病与肠道微生物群相关性的研究进展

Research Advances in the Correlation Between Parkinson’s Disease and Intestinal Microbiota

摘要

帕金森病(Parkinson’s disease, PD)严重威胁中老年人群的健康, 但其病因目前尚不完全清楚。近年来的研究发现, 帕金森病的发生与肠道微生物群密切相关, 肠道微生物群通过微生物-肠-脑轴影响机体的肠屏障通透性、炎症氧化应激水平以及神经递质的释放等, 从而参与到帕金森病的进程中。饮食干预、适宜益生菌补充、粪菌移植等能有效缓解或改善帕金森病患者的症状, 为帕金森病的治疗提供了新的思路。不过, 鉴于不同人群间肠道微生物群极大的异质性, 有关帕金森病与肠道微生物群的相关性研究仍任重道远。

Abstract

Parkinson’s disease (PD) is a serious threat to the health of middle-aged and elderly people. The etiology of the disease remains unclear. Recent studies have found that the occurrence of PD is closely related to the intestinal microbiome, which is involved in the process of PD by affecting the intestinal barrier permea-bility, inflammation and oxidative stress levels and the release of neurotransmitters through the microbe-gut-brain axis. Dietary intervention, supplementation with suitable probiotics and fecal microbiota transplantation (FMT) can effectively alleviate or improve the symptoms of PD, and may be useful to treat the disease. However, due to the great heterogeneity of gut microbes, much work needs to be done to reveal the correlation between PD and intestinal microbiome.

关键词

帕金森病(PD) / 肠道微生物群 / 微生物-肠-脑轴

Key words

Parkinson’s disease (PD) / intestinal microbiota / microbe-gut-brain axis