miRNA在阿霉素相关心脏毒性中调控作用的研究进展

Research Progress of MicroRNAs in Regulating Doxorubicin-related Cardiotoxicity

摘要

心脏毒性是抗肿瘤药物阿霉素(doxorubicin, DOX)临床应用的主要限制之一, 会促进严重心血管并发症的发展, 这是一个亟待解决的健康问题。尽管经过了多年研究, 但心脏毒性的机制仍然不清楚, 也没有有效的早期预测或治疗方法。因此, 需要进一步了解心脏毒性的发生机制, 以确保在心肌发生不可逆损伤之前制定早期预防或治疗策略。近年来, 微RNA (microRNA, miRNA)在阿霉素诱导的心脏毒性(doxorubicin-induced cardiotoxicity, DIC)中的作用引起了人们的广泛关注, miRNA可能通过多种途径调控DIC的发生与发展, 被认为是一个很有希望的探索领域。本文综述了DIC中与miRNA相关的前沿研究, 探讨了使用miRNA作为治疗靶点的可能性和前景, 并分析了其应用的局限性和挑战。

Abstract

Cardiotoxicity is one of the main limitations of antitumor drug doxorubicin (DOX) in clinical use. It can aggravate cardiovascular problems and is regarded as a serious medical issue that needs to be addressed urgently. Despite years of research, the mechanism of cardiotoxicity is still unknown, and there is no effec-tive method for early predication or treatment. Therefore, further understanding of its mechanism is needed to develop early prevention or treatment strategies and to avoid irreversible damage to the myocardium. The roles of microRNAs (miRNAs) in DOX-induced cardiotoxicity (DIC) have drawn wide attention recently. mi-RNAs control the occurrence and progression of DIC in many ways, and may become a promising break-through in coping with DIC. This paper reviewed the progress of miRNAs associated with DIC, the possibility and prospect of using miRNAs as therapeutic targets, and the limitations and challenges of their application.

关键词

阿霉素(DOX) / 心脏毒性 / 微RNA (miRNA) / 氧化应激 / 线粒体损伤 / 自噬 / 凋亡

Key words

doxorubicin (DOX) / cardiotoxicity / microRNA (miRNA) / oxidative stress / mitochondrial damage / autophagy / apoptosis