群体感应信号分子AIP功能与作用机制研究进展

Research Progress on Function and Mechanisms of AIPs: A Kind of Quorum Sensing Signal Molecules

摘要

群体感应(quorum sensing, QS)是微生物种群之间、微生物群落与植物之间相互作用的重要途径。调控群体感应过程的信号分子称为自诱导物(autoinducer, AI), 它们在生物发光、毒力因子分泌、孢子形成、次级代谢物合成以及生物膜的形成过程中均发挥着重要的调控作用。自诱导寡肽(autoinducing peptide, AIP)是细菌群落之间特异性交流的群体感应信号分子之一。本文综述了AIP的来源、结构、功能与作用机制方面的研究进展, 讨论了AIP在植物促生和生防中的应用潜力, 以期更好地理解微生物群落生态功能及其与植物互作的分子机制, 为群体感应信号分子在生态农业中的应用提供理论基础。

Abstract

Quorum sensing (QS) is an important way of interaction between microbial populations and between microbial communities and plants. The signaling molecules that regulate the quorum sensing process are called autoinducers (AIs), which play important regulatory roles in bioluminescence, virulence factor secretion, spore formation, secondary metabolite synthesis, and biofilm formation. Autoinducing peptides (AIPs) are one kind of the quorum sensing signaling molecules that specifically communicate between bacterial communi-ties. This article reviewed the research progress in the source, structure, function and mechanisms of AIPs, and discussed their application potentials in plant growth promotion and biocontrol. It would be beneficial for better understanding the ecological function of microbial community and the molecular mechanism of in-teraction with plants, and may provide some help for the application of quorum sensing signaling molecules in ecological agriculture.

关键词

群体感应信号分子 / 自诱导寡肽(AIP) / 作用机制

Key words

quorum sensing signal molecule / autoinducing peptide (AIP) / mechanism