环状RNA与激素性股骨头坏死发病机制的相关性研究

Correlation Between Circular RNAs and Pathogenesis of Steroid-induced Necrosis of the Femoral Head

摘要

激素性股骨头坏死(steroid-induced necrosis of the femoral head, SANFH)作为髋关节常见疾病, 早期诊断及治疗较为困难, 寻找SANFH分子生物标志物对其早期诊断具有重要意义。环状RNA (circular RNA, circRNA)是一类闭合环状非编码RNA (non-coding RNA, ncRNA), 可通过海绵吸附微RNA (microRNA, miRNA)、结合RNA结合蛋白(RNA-binding protein, RBP)、直接翻译蛋白质、调控基因表达等方式参与众多疾病的发生发展, 是机体重要的调控因子。近年来, 诸多研究基于circRNA探讨SANFH发病机制。本文就circRNA的生物学特征、功能, 以及其在作为SANFH发病机制的血管微循环障碍、脂代谢紊乱、骨代谢异常中的调控作用进行综述, 探讨circRNA作为早期诊断SANFH生物标志物的可能性。

Abstract

Steroid-induced necrosis of the femoral head (SANFH) is a common disease of the hip joints, and its early diagnosis and treatment are difficult. Finding molecular biomarkers of SANFH is of great signifi-cance for its early diagnosis. Circular RNAs (circRNAs) are a kind of closed circular non-coding RNAs (nc-RNAs), which are involved in the occurrence and development of many diseases by adsorbing microRNAs (miRNAs) like sponges, binding RNA-binding proteins (RBPs), directly translating proteins, regulating gene expression and so on. They are important regulatory factors in the body. In recent years, many studies have explored the pathogenesis of SANFH based on circRNAs. This article reviews the biological characteristics, functions, and regulatory roles of circRNAs in vascular microcirculation, lipid metabolism, and bone meta-bolism related to pathogenesis of SANFH, and discusses the potential roles of circRNAs as biomarkers for diagnosing early-stage SANFH.

关键词

激素性股骨头坏死(SANFH) / 环状RNA (circRNA) / 生物学功能 / 发病机制 / 生物标志物

Key words

steroid-induced necrosis of the femoral head (SANFH) / circular RNA (circRNA) / biological function / pathogenesis / biomarker