In order to solve the problems of unclear smoke disaster mechanism and difficult evacuation in urban “multi-in-one” building fires, the fire dynamics simulation (FDS) method was used to construct a numerical model of a typical case and carry out the whole process fire simulation research. The results show that the heat release rate (HRR) curve has the stage characteristics of rising, stable, rapid decline and slow decline; the change of HRR was significantly correlated with CO volume fraction, temperature and visibility, and was weakly correlated with effective dose fraction (FED). The burn-through of the sandwich color steel plate wall is the key node of the disaster, and the smoke toxicity and extinction are the main disaster-causing factors. The evacuation time of about 120 s can be obtained by controlling the growth rate of HRR and the smoke flow. The technical defense path of “chain-breaking disaster reduction” proposed by provides a theoretical basis for formulating fire prevention and control measures for such buildings.
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