中国儿童输血依赖型地中海贫血输血管理指南（2025年）

Guideline for transfusion management in Chinese children with transfusion-dependent thalassemia (2025)

摘要

地中海贫血是一组由于血红蛋白合成障碍导致无效红细胞生成的遗传性疾病，临床表现为轻重不等的慢性贫血。输血依赖型地中海贫血患者终生依赖规律输血和祛铁治疗，规范的输血治疗和正确的输血并发症处理可以保证儿童患者的生长发育和提高患者的生存质量。该指南制订工作组参考国内外指南、专家共识和相关研究，形成这部指南，旨在进一步规范我国儿童输血依赖型地中海贫血的输血管理。

Abstract

Thalassemia is a group of hereditary disorders characterized by ineffective erythropoiesis due to hemoglobin synthesis abnormalities, resulting in varying degrees of chronic anemia. Patients with transfusion-dependent thalassemia rely on lifelong regular blood transfusions and iron chelation therapy. Proper transfusion treatment and management of transfusion-related complications are essential to ensure the growth and development of pediatric patients and to improve their quality of life. The guideline working group has developed the guideline by referencing domestic and international guidelines, expert consensus, and relevant studies. The aim is to further standardize the transfusion management of transfusion-dependent thalassemia in children in China.

关键词

输血依赖型地中海贫血 / 输血 / 管理 / 指南 / 儿童

Key words

Transfusion-dependent thalassemia / Blood transfusion / Management / Guideline / Child