老龄化相关的女性盆底功能障碍生物力学考量因素认知进展

Cognitive advances on biomechanical considerations of female pelvic floor dysfunction in the context of aging

摘要

伴随老龄化社会来临，女性盆底功能障碍性疾病发病率持续攀升。本文结合近年文献综述了老年女性盆底功能障碍（特别是盆腔器官脱垂）生物力学研究领域的新进展，以年龄为风险参数，涵盖炎症与代谢、盆底肌筋膜整体连接性、分子信号通路与组织硬度、人工智能赋能的磁共振测量技术，以及临床疗效评估与整体疾病管理等方面的认知范式与干预措施的转变。同时探讨了老年女性盆底功能障碍治疗模式的演变趋势:从单一结构修复转向以机械稳态、代谢平衡及患者个体化需求“三位一体”为核心的个性化治疗方案与发展方向。

Abstract

With the advent of an aging society, the incidence of female pelvic floor dysfunction disorders keeps rising steadily. This article reviews recent advances in biomechanical research on pelvic floor dysfunction (specifically pelvic organ prolapse) in elderly women by integrating recent literature. Taking age as a risk parameter, it covers the shifts in cognitive paradigms and intervention strategies across multiple domains, including inflammation and metabolism, the overall connectivity of pelvic floor myofascia, molecular signaling pathways and tissue stiffness, artificial intelligence-enabled MRI measurement technology, as well as clinical efficacy evaluation and overall disease management. This article further discusses the evolutionary trend of treatment paradigms for pelvic floor dysfunction in elderly women: a transformation from single-structure repair toward personalized treatment regimens and development directions centered on the “triple-integrity” framework of mechanical homeostasis, metabolic balance, and individual patient needs.

关键词

老龄化 / 女性盆底功能障碍 / 盆腔脏器脱垂 / 盆底生物力学 / 盆底肌筋膜关联 / 组织刚度 / 核磁共振成像 / 聚类分析 / 生命周期管理 / 人工智能

Key words

aging / female pelvic floor dysfunction / pelvic organ prolapse / pelvic floor biomechanics / myofascial holistic connectivity / tissue stiffness / MRI / cluster analysis / life-cycle management / artificial intelligence

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基金资助

国家自然科学基金项目(82260362)